预防和治疗神经炎症的新靶点:小胶质细胞铁积累和铁下垂

IF 3.9 4区医学 Q2 NEUROSCIENCES

ASN NEURO Pub Date : 2022-01-01 DOI:10.1177/17590914221133236

Shunfeng Liu, Xueyuan Gao, Shouhong Zhou

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引用次数: 6

摘要

小胶质细胞在维持中枢神经系统稳态中起着重要作用，是大脑中主要的免疫细胞。在受到内外炎症刺激时，小胶质细胞被激活并释放大量炎症因子，从而导致神经炎症。炎症与小胶质细胞铁积累相互促进，共同促进神经炎症的进展。抑制小胶质细胞铁积聚可预防神经炎症。铁死亡是一种铁依赖性磷脂过氧化驱动型细胞死亡调控。细胞铁积累引起细胞膜磷脂过氧化，破坏细胞膜。最终，这一过程导致细胞铁下垂。小胶质细胞中的铁积累或磷脂过氧化释放大量炎症因子。因此，抑制小胶质细胞铁下垂可能是预防和治疗神经炎症的新靶点。

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New Target for Prevention and Treatment of Neuroinflammation: Microglia Iron Accumulation and Ferroptosis

Microglia play an important role in maintaining central nervous system homeostasis and are the major immune cells in the brain. In response to internal or external inflammatory stimuli, microglia are activated and release numerous inflammatory factors, thus leading to neuroinflammation. Inflammation and microglia iron accumulation promote each other and jointly promote the progression of neuroinflammation. Inhibiting microglia iron accumulation prevents neuroinflammation. Ferroptosis is an iron-dependent phospholipid peroxidation-driven type of cell death regulation. Cell iron accumulation causes the peroxidation of cell membrane phospholipids and damages the cell membrane. Ultimately, this process leads to cell ferroptosis. Iron accumulation or phospholipid peroxidation in microglia releases a large number of inflammatory factors. Thus, inhibiting microglia ferroptosis may be a new target for the prevention and treatment of neuroinflammation.

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来源期刊

ASN NEURO NEUROSCIENCES-

CiteScore

7.70

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： ASN NEURO is an open access, peer-reviewed journal uniquely positioned to provide investigators with the most recent advances across the breadth of the cellular and molecular neurosciences. The official journal of the American Society for Neurochemistry, ASN NEURO is dedicated to the promotion, support, and facilitation of communication among cellular and molecular neuroscientists of all specializations.