利用动态熵变和热成像技术评估癌症进展

IF 0.9 Q4 THERMODYNAMICS
M. K. Manesh, A. Rezazadeh, Tayebeh Modaresi Movahed, H. Mirzaei
{"title":"利用动态熵变和热成像技术评估癌症进展","authors":"M. K. Manesh, A. Rezazadeh, Tayebeh Modaresi Movahed, H. Mirzaei","doi":"10.5541/IJOT.885583","DOIUrl":null,"url":null,"abstract":"Entropy is producing during any irreversible process. In the cancer cells, the entropy generation measures the irreversibility; so, the cancer cells have higher entropy generation than the healthy cells. The entropy generation rate shows the amount of robustness, progression, and invasion of the cancer cells. From a thermodynamic aspect, cancer's origin and growth is an irreversible process, and the thermodynamic variables such as the cell volume, temperature, and entropy will change during this process. In this paper, a procedure based on experimental data is proposed to calculate dynamic entropy generation in the tumoral tissues by dynamic thermography and measurement of tumor size. The dynamic changes in the volume, temperature, and entropy associated with tumor cells over time are tested and evaluated in this regard. An in vivo assay has been developed to measure and analyze these changes. This assay investigated the growth of 4T1 Breast Tumor in 55 BALB/c mice over time. Infrared thermography has been employed to evaluate dynamic temperature changes of the tumors. The computer code has been developed to gather important data from tumoral and healthy mice's images to compute considered temperature differences and entropy generation associated with tumoral tissues. To better evaluate tumor tissue, the Micro PET Images are used to verify volume changes of tumors. The relation between the volume and temperature gradient of tumor cells has detected by measuring during the experiment. The entropy of tumor cells was studying and calculating during the process of tumor changes. Results show that entropy generation as the main concept of thermodynamic is a strong tool for the analysis of cancer cells and has a strong relationship with cancer growth.","PeriodicalId":14438,"journal":{"name":"International Journal of Thermodynamics","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2021-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Evaluation of Cancer Progression Using Dynamic Entropy Changes and Thermography\",\"authors\":\"M. K. Manesh, A. Rezazadeh, Tayebeh Modaresi Movahed, H. Mirzaei\",\"doi\":\"10.5541/IJOT.885583\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Entropy is producing during any irreversible process. In the cancer cells, the entropy generation measures the irreversibility; so, the cancer cells have higher entropy generation than the healthy cells. The entropy generation rate shows the amount of robustness, progression, and invasion of the cancer cells. From a thermodynamic aspect, cancer's origin and growth is an irreversible process, and the thermodynamic variables such as the cell volume, temperature, and entropy will change during this process. In this paper, a procedure based on experimental data is proposed to calculate dynamic entropy generation in the tumoral tissues by dynamic thermography and measurement of tumor size. The dynamic changes in the volume, temperature, and entropy associated with tumor cells over time are tested and evaluated in this regard. An in vivo assay has been developed to measure and analyze these changes. This assay investigated the growth of 4T1 Breast Tumor in 55 BALB/c mice over time. Infrared thermography has been employed to evaluate dynamic temperature changes of the tumors. The computer code has been developed to gather important data from tumoral and healthy mice's images to compute considered temperature differences and entropy generation associated with tumoral tissues. To better evaluate tumor tissue, the Micro PET Images are used to verify volume changes of tumors. The relation between the volume and temperature gradient of tumor cells has detected by measuring during the experiment. The entropy of tumor cells was studying and calculating during the process of tumor changes. Results show that entropy generation as the main concept of thermodynamic is a strong tool for the analysis of cancer cells and has a strong relationship with cancer growth.\",\"PeriodicalId\":14438,\"journal\":{\"name\":\"International Journal of Thermodynamics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2021-05-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Thermodynamics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5541/IJOT.885583\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"THERMODYNAMICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Thermodynamics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5541/IJOT.885583","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"THERMODYNAMICS","Score":null,"Total":0}
引用次数: 2

摘要

熵是在任何不可逆的过程中产生的。在癌症细胞中,熵生成测量不可逆性;因此,癌症细胞具有比健康细胞更高的熵生成。熵生成率显示癌症细胞的鲁棒性、进展和侵袭的量。从热力学角度来看,癌症的起源和生长是一个不可逆的过程,细胞体积、温度和熵等热力学变量在这个过程中会发生变化。本文提出了一种基于实验数据的程序,通过动态热成像和测量肿瘤大小来计算肿瘤组织中的动态熵生成。在这方面测试和评估了与肿瘤细胞相关的体积、温度和熵随时间的动态变化。已经开发了一种体内测定法来测量和分析这些变化。该测定研究了4T1乳腺肿瘤在55只BALB/c小鼠中随时间的生长。红外热成像已被用于评估肿瘤的动态温度变化。开发该计算机代码是为了从肿瘤和健康小鼠的图像中收集重要数据,以计算所考虑的与肿瘤组织相关的温差和熵生成。为了更好地评估肿瘤组织,使用显微PET图像来验证肿瘤的体积变化。通过实验测量,检测了肿瘤细胞体积与温度梯度的关系。肿瘤细胞的熵是在肿瘤发生变化的过程中进行研究和计算的。结果表明,熵产生作为热力学的主要概念是分析癌症细胞的有力工具,并且与癌症的生长有很强的关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of Cancer Progression Using Dynamic Entropy Changes and Thermography
Entropy is producing during any irreversible process. In the cancer cells, the entropy generation measures the irreversibility; so, the cancer cells have higher entropy generation than the healthy cells. The entropy generation rate shows the amount of robustness, progression, and invasion of the cancer cells. From a thermodynamic aspect, cancer's origin and growth is an irreversible process, and the thermodynamic variables such as the cell volume, temperature, and entropy will change during this process. In this paper, a procedure based on experimental data is proposed to calculate dynamic entropy generation in the tumoral tissues by dynamic thermography and measurement of tumor size. The dynamic changes in the volume, temperature, and entropy associated with tumor cells over time are tested and evaluated in this regard. An in vivo assay has been developed to measure and analyze these changes. This assay investigated the growth of 4T1 Breast Tumor in 55 BALB/c mice over time. Infrared thermography has been employed to evaluate dynamic temperature changes of the tumors. The computer code has been developed to gather important data from tumoral and healthy mice's images to compute considered temperature differences and entropy generation associated with tumoral tissues. To better evaluate tumor tissue, the Micro PET Images are used to verify volume changes of tumors. The relation between the volume and temperature gradient of tumor cells has detected by measuring during the experiment. The entropy of tumor cells was studying and calculating during the process of tumor changes. Results show that entropy generation as the main concept of thermodynamic is a strong tool for the analysis of cancer cells and has a strong relationship with cancer growth.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
1.50
自引率
12.50%
发文量
35
期刊介绍: The purpose and scope of the International Journal of Thermodynamics is · to provide a forum for the publication of original theoretical and applied work in the field of thermodynamics as it relates to systems, states, processes, and both non-equilibrium and equilibrium phenomena at all temporal and spatial scales. · to provide a multidisciplinary and international platform for the dissemination to academia and industry of both scientific and engineering contributions, which touch upon a broad class of disciplines that are foundationally linked to thermodynamics and the methods and analyses derived there from. · to assess how both the first and particularly the second laws of thermodynamics touch upon these disciplines. · to highlight innovative & pioneer research in the field of thermodynamics in the following subjects (but not limited to the following, novel research in new areas are strongly suggested): o Entropy in thermodynamics and information theory. o Thermodynamics in process intensification. o Biothermodynamics (topics such as self-organization far from equilibrium etc.) o Thermodynamics of nonadditive systems. o Nonequilibrium thermal complex systems. o Sustainable design and thermodynamics. o Engineering thermodynamics. o Energy.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信