altrenoest治疗可降低三岁温血母马在初始马术训练中的应激反应

IF 1.9 2区 农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
M. Kaps , Anne Lutzer , C. Gautier , C. Nagel , J. Aurich , C. Aurich
{"title":"altrenoest治疗可降低三岁温血母马在初始马术训练中的应激反应","authors":"M. Kaps ,&nbsp;Anne Lutzer ,&nbsp;C. Gautier ,&nbsp;C. Nagel ,&nbsp;J. Aurich ,&nbsp;C. Aurich","doi":"10.1016/j.domaniend.2022.106728","DOIUrl":null,"url":null,"abstract":"<div><p>Horse mares are frequently treated with the progestin altrenogest with the aim to suppress estrous behavior and its negative impact on equestrian performance. Progestogens, however, also have sedative effects in males, and females of different species. The aim of our study was therefore to investigate altrenogest-induced changes in the stress response of female horses during initial equestrian training. Three-yr-old Warmblood mares were randomly assigned to treatment with altrenogest (ALT; 0.044 mg/kg once daily; n = 6) or sunflower oil (CON; n = 5) for 12 wk during training. At predefined steps of the training program (free movement, lunging without and with side reins, lunging with saddle, mounting of a rider, free riding, riding by an unfamiliar rider) salivary cortisol concentration, and heart rate were determined from 60 min before to 120 min after training. The same procedures were performed during repeated gynecologic examinations and 2 novel object tests. Bodyweight and body condition scores (BCS) were assessed at 4-wk intervals. During all training units, salivary cortisol concentration and heart rate increased (<em>P &lt;</em> 0.001), but the increase was smaller in group ALT mares (time x treatment <em>P &lt;</em> 0.001). Gynecologic examinations and novel object tests induced a much smaller increase in cortisol and heart rate (<em>P &lt;</em> 0.001) than equestrian training with no difference between groups ALT and CON. Initially, bodyweight, and BCS decreased during training. The subsequent increase was larger in group ALT vs CON (time x treatment <em>P &lt;</em> 0.05). In conclusion, altrenogest reduced the stress response of 3-yr-old mares to equestrian training. The use of altrenogest during equestrian competitions should therefore be reconsidered.</p></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0739724022000194/pdfft?md5=c38240d726db5c443ac15eefa6c50c05&pid=1-s2.0-S0739724022000194-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Altrenogest treatment reduces the stress response of three-year-old warmblood mares during their initial equestrian training\",\"authors\":\"M. Kaps ,&nbsp;Anne Lutzer ,&nbsp;C. Gautier ,&nbsp;C. Nagel ,&nbsp;J. Aurich ,&nbsp;C. Aurich\",\"doi\":\"10.1016/j.domaniend.2022.106728\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Horse mares are frequently treated with the progestin altrenogest with the aim to suppress estrous behavior and its negative impact on equestrian performance. Progestogens, however, also have sedative effects in males, and females of different species. The aim of our study was therefore to investigate altrenogest-induced changes in the stress response of female horses during initial equestrian training. Three-yr-old Warmblood mares were randomly assigned to treatment with altrenogest (ALT; 0.044 mg/kg once daily; n = 6) or sunflower oil (CON; n = 5) for 12 wk during training. At predefined steps of the training program (free movement, lunging without and with side reins, lunging with saddle, mounting of a rider, free riding, riding by an unfamiliar rider) salivary cortisol concentration, and heart rate were determined from 60 min before to 120 min after training. The same procedures were performed during repeated gynecologic examinations and 2 novel object tests. Bodyweight and body condition scores (BCS) were assessed at 4-wk intervals. During all training units, salivary cortisol concentration and heart rate increased (<em>P &lt;</em> 0.001), but the increase was smaller in group ALT mares (time x treatment <em>P &lt;</em> 0.001). Gynecologic examinations and novel object tests induced a much smaller increase in cortisol and heart rate (<em>P &lt;</em> 0.001) than equestrian training with no difference between groups ALT and CON. Initially, bodyweight, and BCS decreased during training. The subsequent increase was larger in group ALT vs CON (time x treatment <em>P &lt;</em> 0.05). In conclusion, altrenogest reduced the stress response of 3-yr-old mares to equestrian training. The use of altrenogest during equestrian competitions should therefore be reconsidered.</p></div>\",\"PeriodicalId\":11356,\"journal\":{\"name\":\"Domestic animal endocrinology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2022-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0739724022000194/pdfft?md5=c38240d726db5c443ac15eefa6c50c05&pid=1-s2.0-S0739724022000194-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Domestic animal endocrinology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0739724022000194\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Domestic animal endocrinology","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0739724022000194","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 0

摘要

母马经常使用孕激素治疗,目的是抑制动情行为及其对马术表现的负面影响。然而,孕激素在不同物种的雄性和雌性中也有镇静作用。因此,我们研究的目的是研究在初始马术训练中,雌马应激反应的变化。3岁的温血母马被随机分配到ALT治疗组;0.044 mg/kg每日1次;n = 6)或葵花籽油(CON;N = 5),训练12周。在训练计划的预定步骤(自由运动,无缰绳和有缰绳的弓步,有马鞍的弓步,骑在骑手身上,自由骑,由不熟悉的骑手骑),唾液皮质醇浓度和心率从训练前60分钟到训练后120分钟被测定。在重复妇科检查和2次新对象试验中采用相同的程序。每隔4周评估体重和身体状况评分(BCS)。在所有训练单元中,唾液皮质醇浓度和心率增加(P <0.001),但ALT组母马的增加较小(时间x治疗P <0.001)。妇科检查和新对象试验诱导的皮质醇和心率的增加要小得多(P <0.001),与马术训练相比,ALT组和con组之间没有差异。最初,体重和BCS在训练期间下降。ALT组随后的升高幅度大于CON组(时间x治疗P <0.05)。综上所述,altrenoest降低了3岁母马对马术训练的应激反应。因此,应该重新考虑在马术比赛中使用altrenogest。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Altrenogest treatment reduces the stress response of three-year-old warmblood mares during their initial equestrian training

Horse mares are frequently treated with the progestin altrenogest with the aim to suppress estrous behavior and its negative impact on equestrian performance. Progestogens, however, also have sedative effects in males, and females of different species. The aim of our study was therefore to investigate altrenogest-induced changes in the stress response of female horses during initial equestrian training. Three-yr-old Warmblood mares were randomly assigned to treatment with altrenogest (ALT; 0.044 mg/kg once daily; n = 6) or sunflower oil (CON; n = 5) for 12 wk during training. At predefined steps of the training program (free movement, lunging without and with side reins, lunging with saddle, mounting of a rider, free riding, riding by an unfamiliar rider) salivary cortisol concentration, and heart rate were determined from 60 min before to 120 min after training. The same procedures were performed during repeated gynecologic examinations and 2 novel object tests. Bodyweight and body condition scores (BCS) were assessed at 4-wk intervals. During all training units, salivary cortisol concentration and heart rate increased (P < 0.001), but the increase was smaller in group ALT mares (time x treatment P < 0.001). Gynecologic examinations and novel object tests induced a much smaller increase in cortisol and heart rate (P < 0.001) than equestrian training with no difference between groups ALT and CON. Initially, bodyweight, and BCS decreased during training. The subsequent increase was larger in group ALT vs CON (time x treatment P < 0.05). In conclusion, altrenogest reduced the stress response of 3-yr-old mares to equestrian training. The use of altrenogest during equestrian competitions should therefore be reconsidered.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Domestic animal endocrinology
Domestic animal endocrinology 农林科学-奶制品与动物科学
CiteScore
5.50
自引率
4.80%
发文量
58
审稿时长
31 days
期刊介绍: Domestic Animal Endocrinology publishes scientific papers dealing with the study of the endocrine physiology of domestic animal species. Those manuscripts utilizing other species as models for clinical or production problems associated with domestic animals are also welcome. Topics covered include: Classical and reproductive endocrinology- Clinical and applied endocrinology- Regulation of hormone secretion- Hormone action- Molecular biology- Cytokines- Growth factors
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信