Hongzhou Peng , Zijun Gong , Rui Zan , Wei Wang , Han Yu , Yu Sun , Chaolin Ma , Wenhui Wang , Tao Suo , Xiaonong Zhang
{"title":"生物医学Mg-2wt.%Zn合金在胆道环境下的体内外降解行为研究","authors":"Hongzhou Peng , Zijun Gong , Rui Zan , Wei Wang , Han Yu , Yu Sun , Chaolin Ma , Wenhui Wang , Tao Suo , Xiaonong Zhang","doi":"10.1016/j.jma.2022.10.019","DOIUrl":null,"url":null,"abstract":"<div><div>Magnesium and its alloys have been initially applied to biliary tract surgery. Currently, few reports on the degradation behavior of magnesium in the bile environment were investigated. Thus, in-depth research on the degradation behavior of Mg and its alloys in bile is beneficial to the further application of Mg in biliary tract surgery. In this study, the degradation behavior of HP-Mg (HPM) and Mg-2 wt.%Zn (MZ2) alloys in human bile and Hanks balanced salt solution (HBSS) was systematically investigated. The MZ2 alloy biliary stent was implanted into the porcine common bile duct to study the degradation behavior of MZ2 alloy <em>in vivo</em>, and to verify the biosafety of MZ2 alloys degradation in the bile duct. It was found that the degradation product layer formed by MZ2 alloys in bile consisted of three layers, including organic matter (fatty acid, etc.), calcium and magnesium phosphate, and Mg(OH)<sub>2</sub>/MgO, respectively from the outside to the inside. The multi-layered degradation product layer slowed down the corrosion of the Mg matrix. During the 21 days of stent implantation, the degradation rate of the MZ2 stent was about 0.83 mm/y, there was no blockage and stenosis of the tube diameter, and the bile drainage function was normal.</div></div>","PeriodicalId":16214,"journal":{"name":"Journal of Magnesium and Alloys","volume":"13 3","pages":"Pages 1066-1077"},"PeriodicalIF":15.8000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research on the degradation behaviors of biomedical Mg-2 wt.% Zn alloy under a biliary environment in vitro and in vivo\",\"authors\":\"Hongzhou Peng , Zijun Gong , Rui Zan , Wei Wang , Han Yu , Yu Sun , Chaolin Ma , Wenhui Wang , Tao Suo , Xiaonong Zhang\",\"doi\":\"10.1016/j.jma.2022.10.019\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Magnesium and its alloys have been initially applied to biliary tract surgery. Currently, few reports on the degradation behavior of magnesium in the bile environment were investigated. Thus, in-depth research on the degradation behavior of Mg and its alloys in bile is beneficial to the further application of Mg in biliary tract surgery. In this study, the degradation behavior of HP-Mg (HPM) and Mg-2 wt.%Zn (MZ2) alloys in human bile and Hanks balanced salt solution (HBSS) was systematically investigated. The MZ2 alloy biliary stent was implanted into the porcine common bile duct to study the degradation behavior of MZ2 alloy <em>in vivo</em>, and to verify the biosafety of MZ2 alloys degradation in the bile duct. It was found that the degradation product layer formed by MZ2 alloys in bile consisted of three layers, including organic matter (fatty acid, etc.), calcium and magnesium phosphate, and Mg(OH)<sub>2</sub>/MgO, respectively from the outside to the inside. The multi-layered degradation product layer slowed down the corrosion of the Mg matrix. During the 21 days of stent implantation, the degradation rate of the MZ2 stent was about 0.83 mm/y, there was no blockage and stenosis of the tube diameter, and the bile drainage function was normal.</div></div>\",\"PeriodicalId\":16214,\"journal\":{\"name\":\"Journal of Magnesium and Alloys\",\"volume\":\"13 3\",\"pages\":\"Pages 1066-1077\"},\"PeriodicalIF\":15.8000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Magnesium and Alloys\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2213956722002808\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"METALLURGY & METALLURGICAL ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Magnesium and Alloys","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2213956722002808","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"METALLURGY & METALLURGICAL ENGINEERING","Score":null,"Total":0}
Research on the degradation behaviors of biomedical Mg-2 wt.% Zn alloy under a biliary environment in vitro and in vivo
Magnesium and its alloys have been initially applied to biliary tract surgery. Currently, few reports on the degradation behavior of magnesium in the bile environment were investigated. Thus, in-depth research on the degradation behavior of Mg and its alloys in bile is beneficial to the further application of Mg in biliary tract surgery. In this study, the degradation behavior of HP-Mg (HPM) and Mg-2 wt.%Zn (MZ2) alloys in human bile and Hanks balanced salt solution (HBSS) was systematically investigated. The MZ2 alloy biliary stent was implanted into the porcine common bile duct to study the degradation behavior of MZ2 alloy in vivo, and to verify the biosafety of MZ2 alloys degradation in the bile duct. It was found that the degradation product layer formed by MZ2 alloys in bile consisted of three layers, including organic matter (fatty acid, etc.), calcium and magnesium phosphate, and Mg(OH)2/MgO, respectively from the outside to the inside. The multi-layered degradation product layer slowed down the corrosion of the Mg matrix. During the 21 days of stent implantation, the degradation rate of the MZ2 stent was about 0.83 mm/y, there was no blockage and stenosis of the tube diameter, and the bile drainage function was normal.
期刊介绍:
The Journal of Magnesium and Alloys serves as a global platform for both theoretical and experimental studies in magnesium science and engineering. It welcomes submissions investigating various scientific and engineering factors impacting the metallurgy, processing, microstructure, properties, and applications of magnesium and alloys. The journal covers all aspects of magnesium and alloy research, including raw materials, alloy casting, extrusion and deformation, corrosion and surface treatment, joining and machining, simulation and modeling, microstructure evolution and mechanical properties, new alloy development, magnesium-based composites, bio-materials and energy materials, applications, and recycling.