PDE-ODE耦合生物反应器大规模生产聚羟基烷酸酯的优化控制策略

IF 3.8 4区 工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY
A. Tawai, M. Sriariyanun, C. Panjapornpon
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引用次数: 0

摘要

摘要补料分批生物反应器(FBBR)控制策略的开发对提高聚羟基烷酸酯(PHA)的产量起着重要作用。为了开发大规模FBBR中PHA生产的投料策略,本文提出了一种考虑养分分散的基于优化的控制方案。提出了一个耦合偏微分方程和常微分方程模型来描述具有过程约束的轴向分散养分和良好分散微生物动力学。采用分析模型预测控制(AMPC)方法,应用营养素的综合变量来开发实时控制系统。控制目标是通过调节营养物进料速率,在更新的设定点调节PHA浓度;引入过程扰动来评估控制鲁棒性。对补料分批操作进行了仿真实验,研究了所开发的控制器的性能;受控输出被设计为跟踪与生物质浓度相对应的更新设定点。闭环和调节系统的结果表明,与应用的PI控制器相比,所提出的控制策略可以提供更高的生产率(33-38%)。性能测试表明,所开发的控制系统可以应用生物量浓度更新设定值,提供促进PHB积累的最优控制动作,并有效地处理干扰。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Optimization-based control strategy for a large-scale polyhydroxyalkanoates production in a fed-batch bioreactor using a coupled PDE–ODE system
Abstract Control strategy development for fed-batch bioreactor (FBBR) plays an important role in the improvement of polyhydroxyalkanoate (PHA) production. To develop a feeding strategy for PHA production in a large-scale FBBR, an optimization-based control scheme that considers nutrient dispersion is proposed in this work. A coupled partial differential equations and ordinary differential equation model is proposed to describe the axial-dispersed nutrient and well-dispersed microbial dynamics with process constraints. An analytical model predictive control (AMPC) method that applies integrated variables of nutrients is employed to develop the real-time control system. The control objective is to regulate the PHA concentration at the updated set points by adjusting the nutrient feed rates; a process disturbance is introduced to evaluate the control robustness. Simulation experiments of a fed-batch operation are conducted to investigate the performance of the developed controller; the controlled output is designed to track the updated set points corresponding to the biomass concentration. Results of closed-loop and regulatory systems showed that the proposed control strategy could provide more productivity (33–38%) compared to the applied PI controller. The performance test demonstrates that the developed control system could apply the biomass concentration for updating set points, provide the optimal control actions that promote PHB accumulation and handle the disturbance effectively.
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来源期刊
Green Processing and Synthesis
Green Processing and Synthesis CHEMISTRY, MULTIDISCIPLINARY-ENGINEERING, CHEMICAL
CiteScore
6.70
自引率
9.30%
发文量
78
审稿时长
7 weeks
期刊介绍: Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.
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