Association of Vitamin D and Calcium Levels with Thyroid Status in the Southern Region of Saudi Arabia

Thyroid dysfunction is the most prevalent endocrine disorder worldwide. Thyroid hormone has a crucial role in maintaining a wide array of metabolic homeostasis. In addition to calcium and bone metabolism, vitamin D influences nonskeletal activities, including the thyroid gland. Therefore, hypovitaminosis D is considered a risk factor for the emergence of many thyroid dysfunctions. In this investigation, we aimed to investigate the association of vitamin D and serum calcium levels with thyroid dysfunction. In this investigation, 2,735 (1,438 females and 1,297 males) laboratory findings from the public, government hospital laboratories, and medical clinics serving chronic patients in the south region (Asir region) of Saudi Arabia were screened over the course of one year. The vitamin D level was significantly lower in both female and male patients in the hypothyroidism category than in the hyperthyroidism and euthyroidism groups. The influence of total serum calcium level was not significant in any thyroid dysfunction category. A high prevalence of normal levels of total serum calcium was observed in all thyroid status groups. A partial correlation between total serum calcium and vitamin D and TSH among thyroid dysfunction patients demonstrated a significant negative correlation between vitamin D and TSH and a nonsignificant negative correlation between total serum calcium level and TSH among hypothyroidism categories. However, in the hypothyroidism group, total serum calcium demonstrated a negative correlation with TSH, while vitamin D showed a positive correlation with TSH.