Yingchao Su , Jiayin Fu , Shaokang Du , Elias Georgas , Yi-Xian Qin , Yufeng Zheng , Yadong Wang , Donghui Zhu
{"title":"可生物降解的Zn–Sr合金,具有增强的机械性能和生物相容性,用于生物医学应用","authors":"Yingchao Su , Jiayin Fu , Shaokang Du , Elias Georgas , Yi-Xian Qin , Yufeng Zheng , Yadong Wang , Donghui Zhu","doi":"10.1016/j.smaim.2021.12.004","DOIUrl":null,"url":null,"abstract":"<div><p>Zinc (Zn) is a new generation of biodegradable metal as temporary biomedical implants with a promising degradation rate. However, its clinical applications have been limited because of the insufficient mechanical properties. Considering the degradation property and biocompatibility, we proposed Zn–Sr alloys after extrusion treatments to simultaneously improve the mechanical strength and ductility. The <em>in vitro</em> and <em>in vivo</em> degradation and biocompatibility were also evaluated using electrochemical and immersion corrosion tests, various cell and bacterial models, together with subcutaneous and femoral implantations in rats. Results showed that the extruded Zn-0.7Sr alloys exhibited two times higher mechanical strengths (∼120 MPa) and better ductility (∼10%) than the pure Zn counterparts. The Zn–Sr alloys provided enhanced <em>in vitro</em> and <em>in vivo</em> biocompatibility along with promising antibacterial properties.</p></div>","PeriodicalId":22019,"journal":{"name":"Smart Materials in Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2590183421000454/pdfft?md5=ce592af6840a7174c8f4d7fdce36165e&pid=1-s2.0-S2590183421000454-main.pdf","citationCount":"8","resultStr":"{\"title\":\"Biodegradable Zn–Sr alloys with enhanced mechanical and biocompatibility for biomedical applications\",\"authors\":\"Yingchao Su , Jiayin Fu , Shaokang Du , Elias Georgas , Yi-Xian Qin , Yufeng Zheng , Yadong Wang , Donghui Zhu\",\"doi\":\"10.1016/j.smaim.2021.12.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Zinc (Zn) is a new generation of biodegradable metal as temporary biomedical implants with a promising degradation rate. However, its clinical applications have been limited because of the insufficient mechanical properties. Considering the degradation property and biocompatibility, we proposed Zn–Sr alloys after extrusion treatments to simultaneously improve the mechanical strength and ductility. The <em>in vitro</em> and <em>in vivo</em> degradation and biocompatibility were also evaluated using electrochemical and immersion corrosion tests, various cell and bacterial models, together with subcutaneous and femoral implantations in rats. Results showed that the extruded Zn-0.7Sr alloys exhibited two times higher mechanical strengths (∼120 MPa) and better ductility (∼10%) than the pure Zn counterparts. The Zn–Sr alloys provided enhanced <em>in vitro</em> and <em>in vivo</em> biocompatibility along with promising antibacterial properties.</p></div>\",\"PeriodicalId\":22019,\"journal\":{\"name\":\"Smart Materials in Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S2590183421000454/pdfft?md5=ce592af6840a7174c8f4d7fdce36165e&pid=1-s2.0-S2590183421000454-main.pdf\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Smart Materials in Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2590183421000454\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Smart Materials in Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590183421000454","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Engineering","Score":null,"Total":0}
Biodegradable Zn–Sr alloys with enhanced mechanical and biocompatibility for biomedical applications
Zinc (Zn) is a new generation of biodegradable metal as temporary biomedical implants with a promising degradation rate. However, its clinical applications have been limited because of the insufficient mechanical properties. Considering the degradation property and biocompatibility, we proposed Zn–Sr alloys after extrusion treatments to simultaneously improve the mechanical strength and ductility. The in vitro and in vivo degradation and biocompatibility were also evaluated using electrochemical and immersion corrosion tests, various cell and bacterial models, together with subcutaneous and femoral implantations in rats. Results showed that the extruded Zn-0.7Sr alloys exhibited two times higher mechanical strengths (∼120 MPa) and better ductility (∼10%) than the pure Zn counterparts. The Zn–Sr alloys provided enhanced in vitro and in vivo biocompatibility along with promising antibacterial properties.