Association between serum albumin and new-onset hyperuricemia among participants with hypertension

Background and Objective: The prospective relationship between serum albumin and new-onset hyperuricemia is still uncertain. Our current study aimed to examine the association between serum albumin and new-onset hyperuricemia among participants with hypertension, and to explore the potential factors that might modify the association. Methods: This study included 10,617 hypertensive patients with normal uric acid (UA) concentrations (<357 μmol/L) at baseline from the UA Substudy of the China Stroke Primary Prevention Trial (CSPPT). The primary study outcome was new-onset hyperuricemia, which was defined as a UA concentration at the exit visit ≥357 μmol/L in women or ≥417 μmol/L in men. Results: During the median follow-up duration of 4.4 years, 1664 (15.7%) new-onset hyperuricemia cases were documented. Overall, there was a significantly inverse relation of serum albumin with risk of new-onset hyperuricemia (per SD increment; odds ratio [OR], 0.74; 95% confidence interval [CI]: 0.70, 0.79). Consistently, when serum albumin was evaluated as quartiles, compared with participants in the first quartile (<46.1 g/L), a significantly lower risk of new-onset hyperuricemia was observed among those in the fourth quartile (≥51.7 g/L; OR, 0.55; 95% CI: 0.47, 0.65). The findings were consistent among participants with different baseline characteristics. Conclusions: There was a significantly inverse association between serum albumin and risk of new-onset hyperuricemia in adults with hypertension.