Monika Krawietz, C. Garcia, Carsten Pilz, M. Glos, B. Diecker, I. Fietze, T. Penzel
{"title":"呼气减压型CPAP(C-Flex+)与CPAP治疗阻塞性睡眠呼吸暂停同样有效","authors":"Monika Krawietz, C. Garcia, Carsten Pilz, M. Glos, B. Diecker, I. Fietze, T. Penzel","doi":"10.4172/2167-0277.1000268","DOIUrl":null,"url":null,"abstract":"Purpose: Continuous positive airway pressure (CPAP) is the accepted therapy for obstructive sleep apnea \n (OSA). An expiratory pressure relief technology called C-Flex+ has been developed to improve the comfort of CPAP \n therapy. It provides a 2 mbar lower exhalation pressure and an additional flow-based pressure relief at the beginning \n of exhalation. The following study was conducted to investigate whether C-Flex+ was as effective as CPAP in treating \n OSA, and the patients’ preference. \nMethods: 60 newly diagnosed patients with OSA completed this double-blind controlled crossover-study. \n Patients were randomized to one night of C-Flex+ and one of CPAP under full attended polysomnography (PSG). \n A comfort visual analog scale (VAS) ranging from 0 to 10, with 10 being the highest comfort, was completed by all \n patients immediately after each PSG. \nResults: There was no significant difference between the therapy modes in the apnea/hypopnea index (median \n 1.5 events/hour (h) with C-Flex+ (interquartile range (IQR) 0.7 to 3.6) vs. 1.7 events/h with CPAP (IQR 0.8 to 3.8), \n p=0.178). The sleep efficiency, sleep architecture and nocturnal oxygenation were also comparable. Most patients \n preferred C-Flex+ over CPAP (65%, p<0.001). C-Flex+ earned significantly higher ratings in the VAS (8.1 (7.2 to 9.0) \n vs. 7.0 (5.1 to 8.8), p<0.001). \nConclusion: C-Flex+ was as effective as CPAP therapy in treating OSA and patients preferred this mode of \n therapy.","PeriodicalId":73946,"journal":{"name":"Journal of sleep disorders & therapy","volume":" ","pages":"1-5"},"PeriodicalIF":0.0000,"publicationDate":"2017-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CPAP with Pressure Relief during Exhalation (C-Flex+) is as Effective as CPAP in the Treatment of Obstructive Sleep Apnea\",\"authors\":\"Monika Krawietz, C. Garcia, Carsten Pilz, M. Glos, B. Diecker, I. Fietze, T. Penzel\",\"doi\":\"10.4172/2167-0277.1000268\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Purpose: Continuous positive airway pressure (CPAP) is the accepted therapy for obstructive sleep apnea \\n (OSA). An expiratory pressure relief technology called C-Flex+ has been developed to improve the comfort of CPAP \\n therapy. It provides a 2 mbar lower exhalation pressure and an additional flow-based pressure relief at the beginning \\n of exhalation. The following study was conducted to investigate whether C-Flex+ was as effective as CPAP in treating \\n OSA, and the patients’ preference. \\nMethods: 60 newly diagnosed patients with OSA completed this double-blind controlled crossover-study. \\n Patients were randomized to one night of C-Flex+ and one of CPAP under full attended polysomnography (PSG). \\n A comfort visual analog scale (VAS) ranging from 0 to 10, with 10 being the highest comfort, was completed by all \\n patients immediately after each PSG. \\nResults: There was no significant difference between the therapy modes in the apnea/hypopnea index (median \\n 1.5 events/hour (h) with C-Flex+ (interquartile range (IQR) 0.7 to 3.6) vs. 1.7 events/h with CPAP (IQR 0.8 to 3.8), \\n p=0.178). The sleep efficiency, sleep architecture and nocturnal oxygenation were also comparable. Most patients \\n preferred C-Flex+ over CPAP (65%, p<0.001). C-Flex+ earned significantly higher ratings in the VAS (8.1 (7.2 to 9.0) \\n vs. 7.0 (5.1 to 8.8), p<0.001). \\nConclusion: C-Flex+ was as effective as CPAP therapy in treating OSA and patients preferred this mode of \\n therapy.\",\"PeriodicalId\":73946,\"journal\":{\"name\":\"Journal of sleep disorders & therapy\",\"volume\":\" \",\"pages\":\"1-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-05-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of sleep disorders & therapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4172/2167-0277.1000268\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of sleep disorders & therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4172/2167-0277.1000268","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
CPAP with Pressure Relief during Exhalation (C-Flex+) is as Effective as CPAP in the Treatment of Obstructive Sleep Apnea
Purpose: Continuous positive airway pressure (CPAP) is the accepted therapy for obstructive sleep apnea
(OSA). An expiratory pressure relief technology called C-Flex+ has been developed to improve the comfort of CPAP
therapy. It provides a 2 mbar lower exhalation pressure and an additional flow-based pressure relief at the beginning
of exhalation. The following study was conducted to investigate whether C-Flex+ was as effective as CPAP in treating
OSA, and the patients’ preference.
Methods: 60 newly diagnosed patients with OSA completed this double-blind controlled crossover-study.
Patients were randomized to one night of C-Flex+ and one of CPAP under full attended polysomnography (PSG).
A comfort visual analog scale (VAS) ranging from 0 to 10, with 10 being the highest comfort, was completed by all
patients immediately after each PSG.
Results: There was no significant difference between the therapy modes in the apnea/hypopnea index (median
1.5 events/hour (h) with C-Flex+ (interquartile range (IQR) 0.7 to 3.6) vs. 1.7 events/h with CPAP (IQR 0.8 to 3.8),
p=0.178). The sleep efficiency, sleep architecture and nocturnal oxygenation were also comparable. Most patients
preferred C-Flex+ over CPAP (65%, p<0.001). C-Flex+ earned significantly higher ratings in the VAS (8.1 (7.2 to 9.0)
vs. 7.0 (5.1 to 8.8), p<0.001).
Conclusion: C-Flex+ was as effective as CPAP therapy in treating OSA and patients preferred this mode of
therapy.