呼气减压型CPAP(C-Flex+)与CPAP治疗阻塞性睡眠呼吸暂停同样有效

Monika Krawietz, C. Garcia, Carsten Pilz, M. Glos, B. Diecker, I. Fietze, T. Penzel
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引用次数: 0

摘要

目的:持续气道正压通气(CPAP)是公认的治疗阻塞性睡眠呼吸暂停(OSA)的方法。一种名为C-Flex+的呼气压力释放技术已经被开发出来,以提高CPAP治疗的舒适性。它在呼气开始时提供了2毫巴的较低呼气压力和额外的基于流量的压力释放。以下研究旨在调查C-Flex+在治疗OSA方面是否与CPAP一样有效,以及患者的偏好。方法:60例新诊断的OSA患者完成了这项双盲对照交叉研究。患者被随机分为一晚C-Flex+和一晚CPAP,并接受全程多导睡眠图(PSG)检查。所有患者在每次PSG后立即完成从0到10的舒适度视觉模拟量表(VAS),其中10是最高的舒适度。结果:两种治疗模式的呼吸暂停/低通气指数(C-Flex+的中位1.5次事件/小时(IQR)为0.7至3.6)与CPAP的1.7次事件/h(IQR为0.8至3.8),p=0.178)没有显著差异。睡眠效率、睡眠结构和夜间氧合也具有可比性。大多数患者更喜欢C-Flex+而不是CPAP(65%,p<0.001)。C-Flex+在VAS中的评分明显更高(8.1(7.2至9.0)比7.0(5.1至8.8),p<001)。结论:C-Flex+与CPAP治疗OSA一样有效,患者更喜欢这种治疗模式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CPAP with Pressure Relief during Exhalation (C-Flex+) is as Effective as CPAP in the Treatment of Obstructive Sleep Apnea
Purpose: Continuous positive airway pressure (CPAP) is the accepted therapy for obstructive sleep apnea (OSA). An expiratory pressure relief technology called C-Flex+ has been developed to improve the comfort of CPAP therapy. It provides a 2 mbar lower exhalation pressure and an additional flow-based pressure relief at the beginning of exhalation. The following study was conducted to investigate whether C-Flex+ was as effective as CPAP in treating OSA, and the patients’ preference. Methods: 60 newly diagnosed patients with OSA completed this double-blind controlled crossover-study. Patients were randomized to one night of C-Flex+ and one of CPAP under full attended polysomnography (PSG). A comfort visual analog scale (VAS) ranging from 0 to 10, with 10 being the highest comfort, was completed by all patients immediately after each PSG. Results: There was no significant difference between the therapy modes in the apnea/hypopnea index (median 1.5 events/hour (h) with C-Flex+ (interquartile range (IQR) 0.7 to 3.6) vs. 1.7 events/h with CPAP (IQR 0.8 to 3.8), p=0.178). The sleep efficiency, sleep architecture and nocturnal oxygenation were also comparable. Most patients preferred C-Flex+ over CPAP (65%, p<0.001). C-Flex+ earned significantly higher ratings in the VAS (8.1 (7.2 to 9.0) vs. 7.0 (5.1 to 8.8), p<0.001). Conclusion: C-Flex+ was as effective as CPAP therapy in treating OSA and patients preferred this mode of therapy.
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