经鼻内途径脑靶向给药系统的最新进展

Q4 Pharmacology, Toxicology and Pharmaceutics
A. Ainurofiq, Aji Prasetya, Bingah Ginanjar Rahayu, Muhammad Syayiq Al Qadri, Myrat Kovusov, Ophira Evangelista Putri Laksono
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引用次数: 0

摘要

人类神经系统疾病,如神经系统感染、帕金森氏症、阿尔茨海默氏症等神经退行性疾病是严重的病理疾病,已成为公共卫生问题。神经系统疾病的治疗需要一种药物分配机制,使足够数量的药物到达大脑,以达到治疗效果。这是很难实现的传统治疗方法,如口服和注射,因为在药物分布过程中有几个障碍,其中一个障碍是血脑屏障(BBB)的形式。随着目前治疗的发展,药物传递修饰在制药领域越来越多地用于治疗中枢神经系统(CNS)疾病。通过鼻子到大脑的鼻内药物输送系统非常有趣因为这种途径可以通过血脑屏障直接将药物输送到大脑。鼻内途径是脑靶向治疗的首选途径。这是由于鼻内途径能够通过神经通路,即嗅觉神经和三叉神经直接传递药物。通过鼻内途径分配药物,药物将通过血脑屏障,而不是在肝脏进行代谢(首过代谢),这种情况是显著抑制药物向大脑外周转运的障碍。影响鼻内给药的因素有很多,包括影响鼻内给药的参数、给药途径和从鼻子到大脑的机制。一种利用纳米粒子和微粒子测定药物通过嗅粘膜细胞渗透性的体外系统。大鼠实验动物体外实验的阳性结果表明,鼻内药物分布保证了纳米颗粒制剂在药物治疗中的有效性。鉴于必须通过血脑屏障形式的神经系统疾病对治疗方法的有效性影响很大,有必要进一步研究开发经鼻内途径给药的相关研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Developments In Brain-Targeted Drug Delivery Systems via Intranasal Route
Diseases of the human nervous system such as neurological infections, Parkinson's, Alzheimer's, and other neurodegenerative diseases are severe pathological diseases and become a public health problem. Neurological disease in its treatment requires a drug distribution mechanism to reach the brain in sufficient quantities so that therapeutic effectiveness is achieved. This is very difficult to achieve with conventional treatment methods such as oral and injection because there are several obstacles in the process of drug distribution, one of which is an obstacle in the form of a Blood Brain Barrier (BBB). Along with current therapeutic developments, drug delivery modifications in the pharmaceutical field are increasingly being developed for the treatment of central nervous system (CNS) diseases. The intranasal drug delivery system to the brain via the nose is very interesting because this route can deliver drugs directly to the brain via the BBB. The intranasal route is preferred in brain targeting. This is due to the ability of the intranasal route to directly deliver drugs through the neural pathways, namely the olfactory nerve and the trigeminal nerve. By distributing the drug via the intranasal route, the drug will pass through the BBB and not undergo metabolism in the liver (first-pass metabolism), where this condition is a barrier that significantly inhibits the peripheral transport of drugs to the brain. There are several things that influence intranasal drug delivery, including parameters that affect intranasal drug administration, drug administration pathways, and mechanisms from the nose to the brain. An in vitro system that can be used to determine the permeability of drugs by means of nano and microparticles through olfactory mucosa cells. Positive results from in vitro experiments on rat test animals indicate that intranasal drug distribution guarantees the effectiveness of nanoparticle formulations in drug therapy. Seeing the big influence on the effectiveness of treatment methods in neurological diseases that must pass through the barrier in the form of the BBB, it is necessary to have further studies related to developing drug delivery via the intranasal route.
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来源期刊
Farmacja Polska
Farmacja Polska Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
0.40
自引率
0.00%
发文量
54
审稿时长
2 weeks
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