艾滋病毒感染者自评和心理物理嗅觉功能障碍的初步研究

IF 1 4区 医学 Q4 Neuroscience
Vidyulata Kamath, Victor A. Del Bene, Christopher Collette, Alexandra Jacob, Pariya L. Fazeli, David E. Vance
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引用次数: 0

摘要

嗅觉功能丧失与生活质量差、营养不良和抑郁风险增加有关,但很少有研究调查艾滋病毒感染者(MLWH)对嗅觉功能障碍的不知情。方法51名妇女完成了嗅觉自我评定、心理物理气味识别测试、认知测试和评估嗅觉习惯、情绪、认知失败和生活质量的问卷调查。计算嗅觉自评的敏感性和特异性,并采用t检验检验导致自评与心理生理嗅觉功能障碍不一致的因素。结果我们发现33.3% (51 MLWH中的17个)的样本在自我报告和心理物理嗅觉评分之间表现出不一致。那些不知道嗅觉功能障碍的人在日常生活中使用较少的气味产品,但在人口统计学、临床或认知指标上没有其他差异。结论:我们的研究结果与先前对认知正常的老年人、创伤性脑损伤和帕金森病的研究一致,这些研究发现嗅觉自我评定可能无法充分反映一个人的嗅觉状态。我们的工作将这些发现扩展到MLWH,自评和心理物理嗅觉功能障碍的不一致性从35%到61%不等。鉴于我们的样本中自评和心理物理嗅觉的不同比率,心理物理嗅觉测量可能在PLWH的神经心理学评估和临床护理中有用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Pilot Study of Self-Rated and Psychophysical Olfactory Dysfunction in Men Living with HIV

Background

Olfactory loss is associated with poor quality of life, malnutrition, and increased risk of depression, yet few studies have examined unawareness of olfactory dysfunction in men living with HIV (MLWH).

Method

MLWH (n = 51) completed olfaction self-ratings, psychophysical odor identification testing, cognitive measures, and questionnaires assessing smell habits, mood, cognitive failures, and quality of life. The sensitivity and specificity of olfactory self-ratings was calculated, and t-tests were used to examine factors contributing to discordance between self-rated and psychophysical olfaction dysfunction.

Results

We found that 33.3% (17 of 51 MLWH) of our sample demonstrated discordance between self-reported and psychophysical olfactory scores. Those unaware of olfaction dysfunction reported using less scented products in daily life but showed no other differences across demographic, clinical, or cognitive indices.

Conclusions

Our results cohere with prior studies of cognitively normal older adults, traumatic brain injury, and Parkinson’s disease, which found that olfactory self-ratings may inadequately capture the full range of a person’s olfactory status. Our work extends these findings to MLWH, with discordance rates ranging from 35 to 61% for self-rated and psychophysical olfactory dysfunction.

Implications

Given the differing rates of self-rated and psychophysical olfaction in our sample, psychophysical olfactory measures may be useful to consider in the neuropsychological assessment and clinical care of PLWH.

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来源期刊
Chemosensory Perception
Chemosensory Perception 农林科学-神经科学
CiteScore
2.50
自引率
0.00%
发文量
8
审稿时长
>36 weeks
期刊介绍: Coverage in Chemosensory Perception includes animal work with implications for human phenomena and explores the following areas: Identification of chemicals producing sensory response; Identification of sensory response associated with chemicals; Human in vivo response to chemical stimuli; Human in vitro response to chemical stimuli; Neuroimaging of chemosensory function; Neurological processing of chemoreception; Chemoreception mechanisms; Psychophysics of chemoperception; Trigeminal function; Multisensory perception; Contextual effect on chemoperception; Behavioral response to chemical stimuli; Physiological factors affecting and contributing to chemoperception; Flavor and hedonics; Memory and chemoperception.
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