高硼酸盐网络作为调节治疗性金属离子镓和锶时间释放的平台

Q1 Materials Science

Biomedical Glasses Pub Date : 2017-04-25 DOI:10.1515/bglass-2017-0002

K. O’Connell, U. Werner‐Zwanziger, H. O’Shea, D. Boyd

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引用次数: 2

摘要

摘要评价了Ga2O3:Na2O取代量的增加对六种季铵高硼酸盐玻璃结构和相关性能的影响。在模拟生理条件下，对提取后的组分离子释放，特别是镓离子释放进行了研究。通过组分离子释放和释放半衰期的增加，Ga2O3:Na2O的取代增加（即0:1-6:4）导致玻璃网络的不稳定。然而，当Ga2O3:Na2O比例≥6:4时，网络稳定出现，导致B、Sr和Ga在提取720小时时的离子释放半衰期和总离子释放减少。每种玻璃组合物提供锶的线性释放曲线，组合物GB202（70B2O3-20SrO-6Na2O-4Ga2O3）和GB203（70B2O3-20SrO-4Na2O-6Ga2O3）提供镓的线性释放剖面长达720小时。11B MAS NMR显示，用Ga2O3取代Na2O（在所研究的组成范围内）导致三倍配位的B[3]基团线性增加，而牺牲了B[4]基团。该数据表明了与网络稳定相关的GaO4四面体的潜在形成。

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High Borate Networks as a Platform to Modulate Temporal Release of Therapeutic Metal Ions Gallium and Strontium

Abstract The effect of increasing substitutions of Ga2O3:Na2O on the structure and contingent properties, of six quaternary high borate glasses was evaluated. Component ion release and particularly gallium ion release was studied post extraction, under simulated physiological conditions. Increasing substitutions of Ga2O3:Na2O (i.e. 0:1 - 6:4) resulted in destabilization of the glass network, observed by increases in component ion release and half-life of release. However, at ≥ 6:4 Ga2O3:Na2O ratio, network stabilization appeared to occur, resulting in a decrease in ion release half-life and total ion release for B, Sr, and Ga at 720 h of extraction. A linear release profile for strontium was provided by each glass composition, and for gallium by composition GB202 (70B2O3-20SrO-6Na2O-4Ga2O3) and GB203 (70B2O3-20SrO-4Na2O-6Ga2O3) for up to 720 h. 11B MAS NMR reveals that the replacement of Na2O with Ga2O3 (in the studied composition range) causesa linear increase of three-fold coordinated B[3] groups at the expense of B[4] groups. The data indicates the potential formation of GaO4-tetrahedra, associated with network stabilization.

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.