丙二醛而非甲基乙二醛损害胰岛素信号、一氧化氮生成和内皮屏障

IF 1.1 Q4 CELL BIOLOGY

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Pub Date : 2021-06-10 DOI:10.1134/S1990747821030089

M. V. Samsonov, N. V. Podkuychenko, V. Z. Lankin, A. V. Vorotnikov, V. P. Shirinsky

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引用次数: 1

摘要

血脂异常和高血糖是2型糖尿病(T2DM)的“因果关系”。它们与膜脂过氧化和氧化葡萄糖转化产生的丙二醛(MDA)和甲基乙二醛(MGO)有关。我们比较了外源性MDA和MGO对人脐静脉内皮细胞的影响，发现MDA而不是MGO会损害胰岛素对pi3激酶途径的激活、NO的产生和内皮屏障能力。MDA可抑制Akt和eNOS的胰岛素激活，但对IRS无影响。这些结果证实了MDA可能作为T2DM发展的早期事件参与内皮功能障碍的假设。

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Malondialdehyde but Not Methylglyoxal Impairs Insulin Signaling, NO Production, and Endothelial Barrier

Dyslipidemia and hyperglycemia portray “cause-and-consequence” of type 2 diabetes mellitus (T2DM). They are linked to malondialdehyde (MDA) and methylglyoxal (MGO) generation that result from membrane lipid peroxidation and oxidative glucose conversions. We compared the effects of exogenous MDA and MGO on human umbilical vein endothelial cells and found that MDA but not MGO impairs insulin activation of PI3-kinase pathway, NO production, and endothelial barrier capacity. MDA abolished insulin activation of Akt and eNOS but not that of IRS. These results substantiate the hypothesis that MDA may be involved in endothelial dysfunction as an early event in the development of T2DM.

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来源期刊

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology CELL BIOLOGY-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.