{"title":"丝裂霉素c对大鼠雄性生殖器官的毒性病理作用","authors":"H. Naji, K. G. Chelab, A. Rhyaf","doi":"10.29079/VOL17ISS2ART517","DOIUrl":null,"url":null,"abstract":"The aim of present study was detected the effect of Mitomycin-c on the histological structure on male reproductive organ. In this study used (24) healthy adult male rats were divided into three groups, each group includes (8) animals: the 1 toxic group was injected (6.5mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, the 2ed therapeutic or low dose group was injected (3.25 mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, while the 3 control group was injected physiological normal saline (0.9% NaCl2). The experimental period was (10) weeks. Animal, which were treated with Mitomycin-c along the period of experiment showed, sever pathological changes, particularly in testes and epididymis.","PeriodicalId":32194,"journal":{"name":"AlQadisiyah Journal of Veterinary Medicine Sciences","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Toxic pathological effect of mitomycin-c on male reproductive organs in rat\",\"authors\":\"H. Naji, K. G. Chelab, A. Rhyaf\",\"doi\":\"10.29079/VOL17ISS2ART517\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The aim of present study was detected the effect of Mitomycin-c on the histological structure on male reproductive organ. In this study used (24) healthy adult male rats were divided into three groups, each group includes (8) animals: the 1 toxic group was injected (6.5mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, the 2ed therapeutic or low dose group was injected (3.25 mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, while the 3 control group was injected physiological normal saline (0.9% NaCl2). The experimental period was (10) weeks. Animal, which were treated with Mitomycin-c along the period of experiment showed, sever pathological changes, particularly in testes and epididymis.\",\"PeriodicalId\":32194,\"journal\":{\"name\":\"AlQadisiyah Journal of Veterinary Medicine Sciences\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"AlQadisiyah Journal of Veterinary Medicine Sciences\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29079/VOL17ISS2ART517\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"AlQadisiyah Journal of Veterinary Medicine Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29079/VOL17ISS2ART517","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Toxic pathological effect of mitomycin-c on male reproductive organs in rat
The aim of present study was detected the effect of Mitomycin-c on the histological structure on male reproductive organ. In this study used (24) healthy adult male rats were divided into three groups, each group includes (8) animals: the 1 toxic group was injected (6.5mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, the 2ed therapeutic or low dose group was injected (3.25 mg/kg) of Mitomycin-c subcutaneous (s/c) once daily, while the 3 control group was injected physiological normal saline (0.9% NaCl2). The experimental period was (10) weeks. Animal, which were treated with Mitomycin-c along the period of experiment showed, sever pathological changes, particularly in testes and epididymis.
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