龙柏叶水提物对白化大鼠原油毒性的影响

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2021-06-14 DOI:10.1080/10496475.2021.1934215

K. Akinwunmi, C. Amadi, M. Awodiran

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引用次数: 0

摘要

摘要本研究评估了紫檀叶水提取物对大鼠原油毒性的改善潜力。研究了在白化病大鼠日粮中同时施用密氏叶提取物和受水溶性原油污染的日粮对其生化和染色体指标的影响。用受原油污染的饮食喂养大鼠，并以100、300或500 mg kg−1 bwt的剂量给药密氏P.mildbraedii叶提取物水溶液，持续6周。测定了实验大鼠血浆中丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶、碱性磷酸酶、乳酸脱氢酶和肌酸酐激酶MB的活性，以及总蛋白、白蛋白、总胆红素、肌酸酐和尿素的浓度。对从大鼠股骨获得的骨髓细胞进行染色体畸变评分。结果表明，施用米曲叶提取物使血浆酶、血液蛋白、尿素和肌酐水平恢复到接近正常对照水平，而原油污染的饮食会改变这些水平，并且治疗大鼠的染色体畸变数量比未治疗的醉酒大鼠少。

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The effect of aqueous leaf extracts of Pterocarpus mildbraedii on crude oil-induced toxicity in Albino rats

ABSTRACT This study evaluated the ameliorative potential of the aqueous leaf extracts of Pterocarpus mildbraedii against crude oil-induced toxicity in rats. The effects of co-administration of the P. mildbraedii leaf extract with diets contaminated with water-soluble fraction of crude oil on biochemical and chromosomal indices in albino rats were studied. Rats were fed with the crude oil-contaminated diets and administered the aqueous P. mildbraedii leaf extract at 100, 300, or 500 mg kg−1 bwt for 6 weeks. The activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and creatinine kinase-MB (CK-MB) as well as the concentrations of total protein, albumin, total bilirubin, creatinine, and urea in the plasma of experimental rats were estimated. Bone marrow cells obtained from the femurs of the rats were scored for chromosomal aberrations. Results showed that the administration of the P. mildbraedii leaf extract restored the levels of the plasma enzymes, blood proteins, urea, and creatinine close to normal control levels, which were altered by the crude oil-contaminated diet, and the number of chromosomal aberrations were fewer in treated rats than in the untreated intoxicated rats.

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.