Clinical Spread of Low Carbohydrate Diet (LCD)

Historically speaking, Low Carbohydrate Diet (LCD) was launched in 1980-1990 by two known investigators in European and North American regions [6,7]. After that, LCD has been recognized and accepted for many people in comparison of Calorie Restriction (CR). One of the reasons was that the exchange carbohydrates with greater intake of protein or fat have gained clinical efficacy [8,9]. They include ability of LCD to bring remarkable weight reduction in short-term [10]. On the other hand, there have been conflicting and incomplete results for long-term clinical influence for health outcomes [11,12]. Furthermore, data from meta-analyses such as some large cohort studies have suggested possible relationship between low carbohydrate intake and elevated mortality rate [13,14].