大剂量抗性淀粉对人血糖反应的影响

Ma Tongyu, Lee Chong-Do
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引用次数: 3

摘要

这项研究考察了在普通松饼中添加高剂量抗性淀粉(RS)对久坐和腹部肥胖人群血糖反应的影响。共有8名参与者被随机分配到两个治疗序列(AB,BA),采用2×2随机交叉设计。用含有75g可消化碳水化合物和30g RS的松饼作为治疗条件(TRT,B)测试治疗效果,而用75g口服葡萄糖溶液作为对照条件(CON,a)测试对照效果。线性混合模型用于测试序列(AB与BA)、治疗(TRT与CON)和时间段对调整协变量(即年龄、性别和种族)后2小时血糖值和曲线下面积(AUC)的影响。TRT的餐后2小时葡萄糖AUC显著低于CON(12.5 vs.15.6 mmol/L•h,P=0.002)。TRT的葡萄糖水平也分别显著低于30分钟(6.6 vs.8.3 mmol/L,P=0.001)、60分钟(6.6 vs 8.5 mmol/L,P=0.004)和90分钟(6.3 vs.8.1 mmol/L,=0.003)时的CON。TRT的餐后2小时胰岛素AUC也显著低于CON(P<0.001)。根据2小时葡萄糖增量AUC值,补充RS的松饼的计算血糖指数为48(葡萄糖=100)。这项研究表明,添加30克RS补充剂可以降低久坐和腹部肥胖成年人松饼的血糖指数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of High Dose Resistant Starch on Human Glycemic Response
This study examined the effect of adding a high dose of resistant starch (RS) in plain muffins on human glycemic response in sedentary and abdominally obese individuals. A total of 8 participants were randomly assigned to two sequences of treatments (AB, BA) using a 2 × 2 randomized cross-over design. The treatment effect was tested with a muffin that contained 75g of digestible carbohydrates and 30g of RS as treatment condition (TRT, B), while the control effect was tested using a 75-g oral glucose solution as a control condition (CON, A). Linear mixed models were used to test the effects of sequence (AB vs. BA), treatment (TRT vs. CON), and time periods on 2-h glucose values and area under the curve (AUC) after adjustment for covariates (i.e., age, sex, and race). The 2-h postprandial glucose AUC was significantly lower in the TRT than the CON (12.5 vs. 15.6 mmol/L•h, P = 0.002). The glucose levels were also significantly lower in the TRT than did the CON at 30 minutes (6.6 vs. 8.3 mmol/L, P = 0.001), 60 minutes (6.6 vs. 8.5 mmol/L, P = 0.004), and 90 minutes (6.3 vs. 8.1 mmol/L, P = 0.003), respectively. The 2-h postprandial insulin AUC was also significantly lower in the TRT than the CON (P < 0.001). Based on the 2-h glucose incremental AUC values, the RS-supplemented muffins’ calculated glycemic index was 48 (glucose = 100). This study suggests that adding 30g of RS supplementation decreased the glycemic index of muffins in sedentary and abdominally obese adults.
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