姬松茸水酒精提取物对应激和非应激小鼠的抗抑郁活性

IF 0.9 4区 医学 Q4 PHARMACOLOGY & PHARMACY
I. Haq, M. Aslam, Hammad Ahmed, N. Sultana
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引用次数: 3

摘要

研究了姬松茸水醇提取物(273、819 mg/kg)的抗抑郁活性;(口服)应激和非应激瑞士白化小鼠。小鼠被固定以诱导应激。给应激动物和非应激动物口服氟西汀20 mg/kg,用强迫游泳试验和悬尾试验记录静止时间。同时测定应激和非应激小鼠血浆亚硝酸盐浓度。研究了α1-肾上腺素能受体拮抗剂吡唑嗪(α1-肾上腺素能受体拮抗剂)、对-苯基丙氨酸-色氨酸羟化酶抑制剂(p-CPA)和7-硝基茚唑(nNOS抑制剂)对布氏金丝桃抗抑郁活性的影响。豚鼠和氟西汀可显著降低应激和非应激小鼠的静止时间,显示出显著的抗抑郁活性。运动活动未见明显变化。然而,应激小鼠血浆亚硝酸盐水平也显著降低。水酒精提取物对小鼠有明显的抗抑郁作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antidepressant-like activity of hydroalcoholic extract of Agaricus blazei in stressed and unstressed mice
The aim of this study was to investigate the antidepressant activity of hydroalcoholic extract Agaricus blazei (273 and 819 mg/kg; orally) in stressed and unstressed Swiss albino mice. Mice were immobilized to induce stress. Fluoxetine 20 mg/kg orally was given to stressed and unstressed animals and immobility time was noted by using forced swim test and tail suspension test. The concentration of plasma nitrite was also evaluated in stressed and unstressed mice. The effect of prazosin (α1-adrenoceptor antagonist), p-CPA (parachlorophenylalanine–tryptophan hydroxylase inhibitor) and 7-nitro-indazole (nNOS inhibitor) on the antidepressant activity of A. blazei was also evaluated. A. blazei and fluoxetine significantly decreased the duration of immobility time in stressed and unstressed mice, showing significant antidepressant activity. No substantial change was found in the locomotor activity. However, a significant reduction in the level of plasma nitrite was also noted in stressed mice. Hydroalcoholic extract showed prominent antidepressant activity in mice.
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来源期刊
Bangladesh Journal of Pharmacology
Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
1.50
自引率
18.80%
发文量
4
审稿时长
>12 weeks
期刊介绍: Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.
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