β-纤维蛋白原-455G/A（rs1800790）基因多态性与伊朗妇女反复流产的关系

fSlnmh dnshgh `lwm pzshkhy jhrm Pub Date : 2019-03-01 DOI:10.52547/jmj.17.1.56

Z. Heidari, M. Shokrzadeh, Abbas Mohammadpour

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引用次数: 0

摘要

患者的等位基因率分别为79%和21%，对照组为73%和27% (p= 0.322)。有证据表明，AA突变基因不增加反复流产的风险，两者无显著相关性(p= 0.472)。而GA杂合子相对于GG参考基因型降低了再次流产的风险(OR= 0.44, 95%CI: 0.22 ~ 1.90, P= 0.024)。结论:rs1800790 FGB基因多态性不增加复发性流产风险。

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The association of beta fibrinogen-455 G/A (rs1800790) gene polymorphism with recurrent abortion in Iranian women

alleles was 79% and 21% in patient and 73% and 27% in control groups, respectively (p= 0.322). Evidence indicated the AA mutant gene does not increase the risk of recurrent abortion and there is no significant association (p= 0.472). But GA heterozygote relative to GG reference genotype decrease the risk of recurrent abortion (OR= 0.44, 95%CI: 0.22-1.90, P= 0.024). Conclusion: The results showed that rs1800790 FGB gene polymorphism did not increase the risk of recurrent abortion.

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10 weeks