中药葛根芩连汤治疗溃疡性结肠炎的科学依据

IF 2 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Jinke Huang, Jiaqi Zhang, Yifan Wang, Jing Ma, Xuefei Yang, Xiaoxue Guo, Mikhaĭlenko Lv, Jinxin Ma, Yijun Zheng, Fengyun Wang, Xudong Tang
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引用次数: 7

摘要

目的葛根清连汤是一种治疗溃疡性结肠炎(UC)的中药复方。然而,来自UC GQD系统评价(SR)/荟萃分析(MA)的证据仍然极具争议。为了整理、评估和综合现有证据,我们进行了这项研究。方法从8个数据库中获得GQD治疗UC的SRs/MA。系统评价的方法论质量2(AMSTAR-2)用于评估方法论质量,系统评价和荟萃分析的首选报告项目(PRISMA)用于评估报告质量,建议评估、开发和评估的分级(GRADE)用于评估证据质量。结果获得4个符合条件的SR/MA。根据AMSTAR 2,所有SR/MA都被评为极低质量。根据PRISMA检查表,所有SR/MA均未报告协议和注册信息。对于GRADE,没有发现具有高质量证据的结果测量,并且结果测量的证据质量处于中等至极低水平。结论GQD联合中药治疗UC疗效优于单纯中药治疗。这一发现为UC的治疗提供了一种新的替代策略。然而,由于纳入的SR/MA提供的证据有限,必须谨慎对待这一结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Scientific Evidence of Chinese Herbal Medicine (Gegen Qinlian Decoction) in the Treatment of Ulcerative Colitis
Objectives Gegen Qinlian decoction (GQD), a Chinese herbal compound, has been widely used in the treatment of ulcerative colitis (UC) in China. However, evidence from systematic reviews (SRs)/meta-analyses (MAs) of GQD in UC remains highly controversial. To collate, evaluate, and synthesize the current evidence, we carried out this study. Methods SRs/MAs of GQD for UC were obtained from eight databases. Methodological Quality of Systematic Reviews 2 (AMSTAR-2) was utilized to appraise the methodological quality, Preferred Reporting Item for Systematic Reviews and Meta-Analyses (PRISMA) for reporting quality, and Grading of Recommendations Assessment, Development, and Evaluation (GRADE) for evidence quality. Results Four eligible SRs/MAs were obtained. According to AMSTAR 2, all SRs/MAs were graded as critically low quality. According to PRISMA checklist, all SRs/MAs failed to report the information of protocol and registration. With GRADE, no outcome measure with high-quality evidence was found, and the evidence quality for outcome measures was in the moderate to critically low levels. Conclusions GQD with conventional medicine (CM) seems to be more effective in UC than CM alone. This finding provides a new alternative strategy for the treatment of UC. However, owing to the limitations of the evidence provided by the included SRs/MAs, this conclusion must be treated with caution.
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来源期刊
Gastroenterology Research and Practice
Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.40
自引率
0.00%
发文量
91
审稿时长
1 months
期刊介绍: Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.
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