柠檬罗勒籽提取物、豆类提取物、芝麻提取物的生物学特性以及柠檬罗勒子提取物与水稻挥发物组合对α-葡萄糖苷酶、α-淀粉酶和酪氨酸酶的抑制活性

IF 1.8 Q3 PHARMACOLOGY & PHARMACY
Nopparat Buddhakala, Thitaya Sornkhwann, Sompong Sansenya
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引用次数: 2

摘要

本试验对豆科植物提取物(绿豆(MB)、薏米(JT)、红芸豆(RB)和黑豆(BB))、芝麻提取物(白芝麻(WS)和黑芝麻(BS))和柠檬罗勒子提取物(LB)的生物活性成分含量和生物活性进行了评价。研究了酵母提取物与曲酸、阿卡波糖和5种水稻挥发性化合物联合使用对α-葡萄糖苷酶、α-淀粉酶和酪氨酸酶活性的影响。三种酶的抑制活性和提取物的抗氧化能力与总酚和总黄酮含量密切相关。LB甲醇提取物(LB(ME))的总酚含量、总黄酮含量和抗氧化能力最高。LB水提物(LB(WE))对α-葡萄糖苷酶和酪氨酸酶的抑制作用最强,IC50分别为0.04±0.004和0.14±0.01 mg/mL。相比之下,LB(ME)对α-淀粉酶的抑制作用最强,IC50为0.13±0.01 mg/mL。研究了5种具有α-葡萄糖苷酶、α-淀粉酶和酪氨酸酶抑制活性、低细胞毒性和高抗一氧化氮生成能力的水稻挥发性化合物与LB提取物的酶抑制作用。结果表明,LB(WE)/2-甲氧基-4-乙烯基酚和LB(WE)/2-戊基呋喃对α-葡萄糖苷酶活性具有协同作用。我们还研究了LB提取物与阿卡波糖和曲酸联合对这些酶的抑制作用。结果表明,LB(ME)/阿卡波糖对α-葡萄糖苷酶和α-淀粉酶活性的抑制作用最强,LB(WE)/曲酸对酪氨酸酶活性的抑制作用最强。因此,这些结果表明,使用LB提取物和联合可能是一种有效的治疗糖尿病和黑色素形成的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biological properties of lemon basil seeds extract, legumes extract, sesame seeds extract and the inhibitory activity of the combination of lemon basil seeds extract with rice volatiles compounds against α-glucosidase, α-amylase and tyrosinase

This research was conducted to evaluate the bioactive compounds content and biological activity of legume extract (mung bean (MB), job’s tears (JT), red kidney bean (RB) and black bean (BB)), sesame extract (white sesame (WS) and black sesame (BS)) and lemon basil seed extract (LB). The research also investigated the combined LB extract with kojic acid, acarbose and five rice volatile compounds against α-glucosidase, α-amylase and tyrosinase activity. The inhibitory activity of three enzymes and the extracts’ antioxidant capacity was closely related to the total phenolic and total flavonoid content. LB methanol extract (LB(ME)) had the highest total phenolic content, total flavonoid content and antioxidant capacity. LB water extract (LB(WE)) with the IC50 of 0.04 ± 0.004 and 0.14 ± 0.01 mg/mL had the highest inhibition potent against α-glucosidase and tyrosinase enzymes. In comparison, LB(ME) with the IC50 of 0.13 ± 0.01 mg/mL represented the highest inhibition potent on the α-amylase enzyme. Five rice volatile compounds with the α-glucosidase, α-amylase and tyrosinase inhibitory activity, low cytotoxicity and high anti-nitric oxide production were combined with LB extract to investigate the enzymatic inhibitory effect. The results indicated that LB(WE)/2-methoxy-4-vinylphenol and LB(WE)/2-pentyl furan had a synergic effect on α-glucosidase activity. We also investigated LB extract combined with acarbose and kojic acid against these enzymes. The results showed that LB(ME)/acarbose had the highest inhibition potent on α-glucosidase and α-amylase activity and LB(WE)/kojic acid had the highest on tyrosinase activity. Thus, these results suggest that using LB extract and the combined may be a useful therapeutic approach for diabetes and melanogenesis treatment.

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来源期刊
Advances in Traditional Medicine
Advances in Traditional Medicine PHARMACOLOGY & PHARMACY-
CiteScore
4.30
自引率
0.00%
发文量
50
期刊介绍: Advances in Traditional Medicine (ADTM) is an international and peer-reviewed journal and publishes a variety of articles including original researches, reviews, short communications, and case-reports. ADTM aims to bridging the gap between Traditional knowledge and medical advances. The journal focuses on publishing valid, relevant, and rigorous experimental research and clinical applications of Traditidnal Medicine as well as medical classics. At the same time, the journal is devoted to communication among basic researcher and medical clinician interested in the advancement of Traditional Medicine. Topics covered by the journal are: Medical Classics & History; Biomedical Research; Pharmacology & Toxicology of Natural Products; Acupuncture & Moxibustion; Sasang Constitutional Medicine; Diagnostics and Instrumental Development; Clinical Research. ADTM is published four times yearly. The publication date of this journal is 30th March, June, September, and December.
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