蜂蜜对头颈部恶性肿瘤患者放射性口腔粘膜炎的疗效：系统评价和荟萃分析

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2022-08-23 DOI:10.37290/ctnr2641-452x.21:53-59

Ying-Li Dong, Weiqian Hou, Chong Zhang, Xiaozhong Cao, Zhen-Yu Li

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引用次数: 0

摘要

虽然放疗仍然是头部和颈部癌症治疗的基石，但口腔粘膜炎是一种非常严重的副作用，尤其是III/IV级口腔粘膜炎。口腔粘膜炎不仅严重降低了患者的生活质量，而且影响了患者正在进行的治疗。蜂蜜在口腔粘膜炎修复中的应用前景广阔，但在临床上存在争议。因此，为了进一步确定其在口腔粘膜炎中的作用，在Pubmed、Embase和Cochrane数据库中进行了广泛的文献检索。13项随机对照试验包括899名患者。分析了95%置信区间的合并比值比。结果显示，接受蜂蜜治疗的患者在放疗后出现III/IV级口腔粘膜炎的人数明显减少（OR 0.24，95%CI 0.13-0.44，p<0.001）。蜂蜜与放疗同时服用可降低III/IV级别口腔粘膜炎发生率。因此，在放射治疗期间使用蜂蜜可能是保持耐受性的可行策略。

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Effectiveness of Honey on Radiation-Induced Oral Mucositis Among Patients with Head and Neck Malignancies: A Systematic Review and Meta-Analysis

While radiotherapy remains the cornerstone of head and neck cancer treatment, oral mucositis is a very serious side effect, especially grade III/IV oral mucositis. Oral mucositis not only seriously reduces the quality of life of patients, but also affects the ongoing treatment of patients. Use of honey for the remediation of oral mucositis promising, but clinically controversial. Therefore, to further ascertain its role in oral mucositis, an extensive literature search was performed in the Pubmed, Embase and Cochrane databases. Thirteen randomized controlled trials with 899 patients were included in the analysis. Pooled Odds ratio with 95% confidence intervals was analyzed. The results show that a significantly fewer number of patients treated with honey experienced grade III/IV oral mucositis after radiotherapy (OR 0.24, 95% CI 0.13–0.44, p < 0.001). The administration of honey concurrently with radiotherapy decreased the rate of graded III/IV oral mucositis. Thus, the use of honey during radiotherapy may represent a feasible strategy for preserving tolerance.

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.