铜催化点击反应合成1,2,3-三唑连接的苯并咪唑

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2019-01-01 DOI:10.1515/hc-2019-0016

M. Bakherad, Ali Keivanloo, A. Amin, Amir Farkhondeh

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引用次数: 6

摘要

摘要在50°C的乙醇中，通过铜催化的点击反应，开发了一种合成1,2,3-三唑连接苯并咪唑的有效方法。在没有配体的情况下，通过铜催化的叠氮化物-炔烃环加成反应，成功地使各种芳香族叠氮化物与正丙炔基苯并咪唑反应。该方法具有反应时间短、成本低和纯化程序简单等优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction

Abstract An efficient method has been developed for the synthesis of 1,2,3 triazole-linked benzimidazole through a copper-catalyzed click reaction in ethanol at 50°C. A broad range of aromatic azides were successfully reacted with n-propynylated benzimidazole via copper-catalyzed azide-alkyne cycloaddition reactions in the absence of a ligand. This method offers many advantages including short reaction times, low cost, and simple purification procedures.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.