5 -羟色胺调节正常健康受试者强迫特质与心率变异性的相关性:基于[123I]ADAM和心率变异性测量的SPECT研究

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI:10.9758/cpn.2022.20.2.271

Che Yu Kuo, K. Chen, I. Lee, Huai-Hsuan Tseng, N. Chiu, P. Chen, Yen Kuang Yang, W. Chang

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引用次数: 0

摘要

目的研究5-羟色胺能系统对强迫症（OCD）的影响。然而，OC表现与自主神经系统（ANS）之间的相关性尚不清楚。此外，这种相关性是否可能受到血清素的调节也不确定。方法我们招募了89名健康受试者。通过[123I]ADAM和心率变异性（HRV）测试测量血清素转运蛋白（SERT）的可用性。对OC表现进行症状自评量表-90测试。计算HRV和SERT可用性之间的相互作用，并在SERT水平分层后分析HRV和OC症状之间的相关性，分为两组，在中等水平。结果低频率（LF）、高频率（HF）和连续差均方根（RMSSD）因子之间存在显著的交互作用。此外，OC症状与上述HRV指数之间的显著负相关仅存在于SERT可用性较高的受试者中。结论SERT可用性较高的受试者OC症状可能与ANS调节有关。

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Serotonin Modulates the Correlations between Obsessive-compulsive Trait and Heart Rate Variability in Normal Healthy Subjects: A SPECT Study with [123I]ADAM and Heart Rate Variability Measurement

Objective The impact of serotonergic system on obsessive-compulsive disorder (OCD) is well studied. However, the correlation between OC presentations and autonomic nervous system (ANS) is still unclear. Furthermore, whether the correlation might be modulated by serotonin is also uncertain. Methods We recruited eighty-nine healthy subjects. Serotonin transporter (SERT) availability by [123I]ADAM and heart rate variability (HRV) tests were measured. Symptoms checklist-90 was measured for the OC presentations. The interaction between HRV and SERT availability were calculated and the correlation between HRV and OC symptoms were analyzed after stratified SERT level into two groups, split at medium. Results The interactions were significant in the factors of low frequency (LF), high frequency (HF), and root mean square of successive differences (RMSSD). Furthermore, the significantly negative correlations between OC symptoms and the above HRV indexes existed only in subjects with higher SERT availability. Conclusion OC symptoms might be correlated with ANS regulations in subjects with higher SERT availability.

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.