胎盘冷冻提取物和肾素-血管紧张素-醛固酮系统阻断减轻大鼠肾功能衰竭

Q4 Medicine

Problems of Cryobiology and Cryomedicine Pub Date : 2021-09-25 DOI:10.15407/cryo31.03.223

M. Repin, Yu.V. Chyzh, L. Marchenko, Tetyana Govorukha, Oleksandr Brusentsov

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引用次数: 1

摘要

在此，我们使用甘油模型研究了大鼠胎盘冷冻提取物（PCE）的给药、依那普利和螺内酯对肾素-血管紧张素-醛固酮系统（RAAS）的药物阻断及其组合对慢性肾功能衰竭（CRF）不同发展阶段大鼠肾组织结构和排泄功能的影响。在引入甘油后的3周内，所有组的动物都表现出肾小球滤过率低、肾皮质血流受损、肾小管上皮营养不良、炎症和间质水肿，表明CRF发展的开始。16周后，未经治疗的大鼠主要发生管状间质性肾炎和肾硬化。RAAS药物阻断剂的使用，以及RAAS阻断剂和胎盘冷冻提取物的综合治疗，阻止了肾组织的炎症过程，恢复了血液循环，使排泄功能正常化，并持续了长达16周的观察。

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Placental Cryoextract and Renin-Angiotensin-Aldosterone System Blockade Mitigate Renal Failure in Rats

Here, we have studied the impact of administration of rat placental cryoextract (PCE), drug blockade of the renin-angiotensin-aldosterone system (RAAS) with enalapril and spironolactone and their combination on the rat kidney tissue structure and excretory function at different stages of chronic renal failure (CRF) development using the glycerol model. In 3 weeks after glycerol introduction, the animals from all the groups showed low values of glomerular filtration rate, impaired blood flow in renal cortex, tubular epithelial dystrophy, inflammation and edema of interstitium, indicating the onset of CRF development. Tubulo-interstitial nephritis and nephrosclerosis were dominated in untreated rats 16 weeks later. The use of RAAS drug blockade, as well as a comprehensive therapy with RAAS blockers and placental cryoextract stopped the inflammatory processes in renal tissue, restored blood circulation and normalized excretory function, which persisted for up to 16 weeks of observation.

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来源期刊

Problems of Cryobiology and Cryomedicine Medicine-Medicine (miscellaneous)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The Journal publishes the reviews and original papers on cryobiological and cryomedical research, in particular the elucidation of mechanisms of injuries occurring in biological objects and caused by the influence of low and ultra low temperatures; natural resistance of biologicals to cold and their recovery post effect; the development of effective methods of cryoprotection and technology of storage of biological resources under hypothermic and ultra low temperatures, application of hypothermia, cryotherapy and cryopreserved biologicals for treating various pathologies; cell and tissue based therapies and other issues of low-temperature biology and medicine, as well as development of devices and equipment for low temperature biology and medicine. The journal covers all topics related to low temperature biology, medicine and engineering. These include but are not limited to: low temperature storage of biologicals (human, animal or plant cells, tissues, and organs), including preparation for storage, thawing/warming, cell and tissue culturing etc. response of biologicals to low temperature; cold adaptation of animals and plants; utilisation of low temperature in medicine; experimental and clinical transplantation, cell and tissue based therapies; developing of cryobiological and cryomedical devices; organisation and functioning of low temperature banks etc.