生物治疗严重银屑病对外周血树突状细胞的影响

IF 4.1 4区医学 Q2 IMMUNOLOGY

Scandinavian Journal of Immunology Pub Date : 2023-12-01 Epub Date: 2023-08-13 DOI:10.1111/sji.13321

Aleksandra Petrovic, Lisa Lynn Ten Bergen, Silje Michelsen Solberg, Irene Sarkar, Brith Bergum, Richard Davies, Roland Jonsson, Silke Appel

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引用次数: 0

摘要

在使用抗肿瘤坏死因子药物英夫利西单抗（infiximab）、依那西普（etanercept）、抗IL-17A secukinumab和抗IL12/IL-23 ustekinumab治疗前（T1）和治疗12个月后（T2），通过流式细胞术对无寻常型银屑病（PsO；N = 23）或伴有银屑病关节炎（PsA；N = 15）的外周血树突状细胞（DC）群进行深入免疫分型。与健康供体（38 人）相比，PsA 患者的树突状细胞亚群 pDC、cDC1 和 cDC2 的频率较低，治疗后除 pDC 外，其他亚群均恢复正常。相比之下，PsO 患者仅显示出较低的 pDC 频率，但在治疗后恢复正常。图由 BioRender.com 绘制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Biological treatment in severe psoriasis: Influence on peripheral blood dendritic cells.

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Biological treatment in severe psoriasis: Influence on peripheral blood dendritic cells.

In-depth immunophenotyping by flow cytometry of peripheral blood dendritic cell (DC) populations of psoriasis vulgaris without (PsO; N = 23) or with psoriatic arthritis (PsA; N = 15), before (T1) and after 12 months (T2) therapy with the anti-TNF drugs infliximab, etanercept, the anti-IL-17A secukinumab and the anti-IL12/IL-23 ustekinumab. Compared to healthy donors (N = 38), patients with PsA displayed lower frequencies of dendritic cell subsets pDC, cDC1 and cDC2, which were normalized following treatment except pDC. In contrast, patients with PsO only displayed lower frequencies of pDC which were normalized following treatment. Figure created with BioRender.com.

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来源期刊

Scandinavian Journal of Immunology 医学-免疫学

CiteScore

7.70

自引率

5.40%

发文量

109

审稿时长

1 months

期刊介绍： This peer-reviewed international journal publishes original articles and reviews on all aspects of basic, translational and clinical immunology. The journal aims to provide high quality service to authors, and high quality articles for readers. The journal accepts for publication material from investigators all over the world, which makes a significant contribution to basic, translational and clinical immunology.