{"title":"致病机制的研究进展:细菌表面聚糖作为毒力因子及其在致病菌中的作用","authors":"C. Ghazaei, S. Amjad","doi":"10.32802/asmscj.2023.1235","DOIUrl":null,"url":null,"abstract":"Bacterial glycans are essential components of bacterial walls and crucially important cell surface antigens such as lipopolysaccharide and polysaccharide capsules, which act as virulence-causing factors. Polysaccharide capsules in bacteria are naturally composed of recurring oligosaccharides and lipopolysaccharides. LPS is composed of domains that are hydrophobic in nature known as lipid A or endotoxin, which is a nonrepeating oligosaccharide \"core\", and an O-antigen. Interaction of glycan-receptor is critical in pattern recognition of microorganisms and regulatory signals that perform regular immune cell activities. The true glycan structure is important for collaboration with the immune system of host, as demonstrated by microorganisms that produce polycarbohydrates that mimic host particles in order to evade the immunity of host. Certain bacteria circumvent antibody defences by molecularly mimicking the glycan structures of host and masquerade as \"self\" to avoid identification by immune system. Phages are the most prevalent biological entities on our planet, and they evolved glycan-binding proteins (GBPs) to bind to bacterial glycans. These proteins are in charge of the breakdown of antibodies and are impervious to harsh conditions where bacteria live for example, the gut of mammals, water, and soil. In order to increase contact with bacterial glycans, the phages manufacture multimeric proteins.","PeriodicalId":38804,"journal":{"name":"ASM Science Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advances in Understanding the Pathogenesis: Bacterial Surface Glycans as The Virulence Factor and Role in Pathogen Bacteria\",\"authors\":\"C. Ghazaei, S. Amjad\",\"doi\":\"10.32802/asmscj.2023.1235\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Bacterial glycans are essential components of bacterial walls and crucially important cell surface antigens such as lipopolysaccharide and polysaccharide capsules, which act as virulence-causing factors. Polysaccharide capsules in bacteria are naturally composed of recurring oligosaccharides and lipopolysaccharides. LPS is composed of domains that are hydrophobic in nature known as lipid A or endotoxin, which is a nonrepeating oligosaccharide \\\"core\\\", and an O-antigen. Interaction of glycan-receptor is critical in pattern recognition of microorganisms and regulatory signals that perform regular immune cell activities. The true glycan structure is important for collaboration with the immune system of host, as demonstrated by microorganisms that produce polycarbohydrates that mimic host particles in order to evade the immunity of host. Certain bacteria circumvent antibody defences by molecularly mimicking the glycan structures of host and masquerade as \\\"self\\\" to avoid identification by immune system. Phages are the most prevalent biological entities on our planet, and they evolved glycan-binding proteins (GBPs) to bind to bacterial glycans. These proteins are in charge of the breakdown of antibodies and are impervious to harsh conditions where bacteria live for example, the gut of mammals, water, and soil. In order to increase contact with bacterial glycans, the phages manufacture multimeric proteins.\",\"PeriodicalId\":38804,\"journal\":{\"name\":\"ASM Science Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ASM Science Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.32802/asmscj.2023.1235\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Multidisciplinary\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ASM Science Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32802/asmscj.2023.1235","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Multidisciplinary","Score":null,"Total":0}
Advances in Understanding the Pathogenesis: Bacterial Surface Glycans as The Virulence Factor and Role in Pathogen Bacteria
Bacterial glycans are essential components of bacterial walls and crucially important cell surface antigens such as lipopolysaccharide and polysaccharide capsules, which act as virulence-causing factors. Polysaccharide capsules in bacteria are naturally composed of recurring oligosaccharides and lipopolysaccharides. LPS is composed of domains that are hydrophobic in nature known as lipid A or endotoxin, which is a nonrepeating oligosaccharide "core", and an O-antigen. Interaction of glycan-receptor is critical in pattern recognition of microorganisms and regulatory signals that perform regular immune cell activities. The true glycan structure is important for collaboration with the immune system of host, as demonstrated by microorganisms that produce polycarbohydrates that mimic host particles in order to evade the immunity of host. Certain bacteria circumvent antibody defences by molecularly mimicking the glycan structures of host and masquerade as "self" to avoid identification by immune system. Phages are the most prevalent biological entities on our planet, and they evolved glycan-binding proteins (GBPs) to bind to bacterial glycans. These proteins are in charge of the breakdown of antibodies and are impervious to harsh conditions where bacteria live for example, the gut of mammals, water, and soil. In order to increase contact with bacterial glycans, the phages manufacture multimeric proteins.
期刊介绍:
The ASM Science Journal publishes advancements in the broad fields of medical, engineering, earth, mathematical, physical, chemical and agricultural sciences as well as ICT. Scientific articles published will be on the basis of originality, importance and significant contribution to science, scientific research and the public. Scientific articles published will be on the basis of originality, importance and significant contribution to science, scientific research and the public. Scientists who subscribe to the fields listed above will be the source of papers to the journal. All articles will be reviewed by at least two experts in that particular field.