Synthesis and SAR Studies of Potent Antioxidant and Anti-InflammatoryActivities of Imidazole Derived Schiff Base Analogues

A novel sequence of imidazole derived Schiff base analogues 4-23 were synthesized and characterized by spectroscopic and analytical techniques. The in vitro antioxidant activities of these compounds were evaluated by using DPPH, ABTS and DMPD assay. The results exposed that the IC50 of compounds 9, 10, 11, 15, 16, 22 and 23 were lower than that of standards in all the three tested antioxidant assays indicating good activities of these compounds. In vitro anti-inflammatory activities of the synthesized compounds were tested and the outcomes of results were confirmed that the compounds 5, 6, 7, 8, 12, 13, 14 and 21 exhibited excellent anti-inflammatory activity. Preliminary structure-activity relationship revealed that the compounds 9, 10, 11, 15, 16, 22 and 23 with electron donating moiety (OH, OCH3) were found to be excellent antioxidants and compounds 5, 6, 7, 8, 12, 13, 14 and 21 with electron withdrawing moiety (Cl, F, NO2 and Br) were found to be excellent anti-inflammatory agents.