尿AD7c-NTP:阿尔茨海默病的生物标志物

Urine (Amsterdam, Netherlands) Pub Date : 2022-01-01 DOI:10.1016/j.urine.2022.01.001

Mei-mei Kang , Rong Wang

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引用次数: 0

摘要

生物标志物对阿尔茨海默病(AD)的早期诊断具有重要意义。阿尔茨海默病相关的神经丝线蛋白(AD7c-NTP)是“神经丝线蛋白”(NTP)家族的一员，在阿尔茨海默病神经退行性变的早期，脑组织提取物、脑脊液(CSF)和尿液中出现增加。AD7c-NTP水平与痴呆程度相关。与血液和脑脊液生物标志物相比，尿液生物标志物反映生理或病理生理过程更早，尿液收集和储存更方便。在这篇综述中，我们讨论了尿液AD7c-NTP作为AD生物标志物的表征、可行性和发展。

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Perspectives in urine AD7c-NTP: A biomarker for Alzheimer's disease

Biomarkers are important for early diagnosis of Alzheimer's disease (AD) in routine clinical practice and research. Alzheimer-associated neuronal thread protein (AD7c-NTP) is a member of the “neuronal thread protein” (NTP) family, which is increased in brain-tissue extracts, cerebrospinal fluid (CSF) and urine in the early stage of AD neurodegeneration. The level of AD7c-NTP is correlated to the degree of dementia. Compared with blood and CSF biomarkers, urine biomarkers reflect physiological or pathophysiological processes earlier, and urine collection and storage are more convenient. In this review, we discussed the characterization, feasibility and development of urine AD7c-NTP as a biomarker for AD.

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来源期刊

Urine (Amsterdam, Netherlands) Health Informatics, Pathology and Medical Technology, Urology

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审稿时长

99 days