Hepatoprotective Potential Of Phytoconstituents And Vitamins Against Antitubercular Drugs Induced Hepatotoxicity In Albino Rats

This study aims to develop a new hepatoprotective drug from common plants and vitamins that are potent, nontoxic, and cost-effective. The literature search found that Curcuma longa, Zingiber officinale, Terminalia, chebula, and Vitamin A (Vitamin C + Vitamin E) provide hepatoprotective action against drugs-induced hepatotoxicity. A major side effect of antitubercular drugs (ATD) is liver toxicity, which reduces their effectiveness. In this study, Vitamins and Phytoconstituents (Combined extract) were evaluated for their potential hepatoprotective effects against hepatotoxicity induced by antitubercular drugs in Wistar albino rats of either sex. In the study, ethanolic extract of rhizomes of Curcuma longa and Zingiber officinale, fruits of Terminalia chebula, and vitamins C and E were used. As a standard drug, silymarin was also used. For 30 days, albino rats received 7.5 mg/kg isoniazid, 10 mg/kg rifampicin, and 35 mg/kg pyrazinamide orally as a suspension in distilled water. A combined extract plus vitamins (500mg/kg) treatment significantly reduced the hepatic toxicity caused by antitubercular drugs (P<0.05-P<0.001). A combination of extracts + vitamins (500mg/kg) eliminates hepatotoxicity, and the results are close to those of Silymarin, a standard drug. As a result of this study, extracts+vitamins provide protection against liver injury attributed to their hepatoprotective activity, which supports their traditional use.