选定已批准药物的体外和体外抗虫活性研究

Archives of community medicine and public health Pub Date : 2020-11-27 DOI:10.17352/2455-5479.000118

Christopher Arinze Agube, D. Ajaghaku, I. Uzochukwu

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引用次数: 0

摘要

我们研究了一些已批准的药物与蛔虫线粒体富马酸红喹啉还原酶（MRFR）的结合亲和力，MRFR是蛔虫生存的必需酶，以及利用计算机分子对接和15名选定的领先者的体外麻痹和死亡时间，将这些药物重新用作抗宿主药物的可能性。

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In silico and in vitro investigations of antihelmintic activities of selected approved drugs

We investigated the binding affinities of some approved drugs to ascaris suum Mitochondrial Rhodoquinol Fumarate Reductase (MRFR), an essential enzyme for ascaris survival, and the possibility of repurposing these drugs as antihelmintic agents using In silico molecular docking and in vitro paralysis and mortality times of fifteen selected front runners.

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Archives of community medicine and public health

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