使用10kHz重复频率的单个激光进行温控视网膜激光治疗

IF 2.3 Q2 OPTICS
M. Mordmüller, V. Kleyman, M. Schaller, M. Wilson, D. Theisen-Kunde, K. Worthmann, M. Müller, R. Brinkmann
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引用次数: 3

摘要

摘要激光光凝是眼科治疗各种视网膜疾病最常用的方法之一。根据适应症的不同,治疗强度各不相同,从应用特定的微损伤到温和的温度升高而不诱导细胞损伤。特别是对于后者,适当的能量给药仍然是一个具有挑战性的问题,这主要取决于医生的经验。脉冲激光光声温度测量已经证明了其在激光治疗期间自动辐射控制的能力,但由于与传统的连续波治疗激光器的组合,其仪器工作相对较高。本文提出了一种使用10kHz重复频率的单脉冲激光器的简化装置。该装置将用于治疗的仪器以及温度测量和控制结合在一个设备中。为了比较单独的脉冲加热和连续波(cw)组织加热,分别以1kHz的重复频率施加4µJ的脉冲能量来探测温度上升。在60mW的相同平均激光功率的情况下,如预期的那样,在两种照射模式下获得了几乎相同的时间温度过程。通过模型预测控制(MPC)和扩展卡尔曼滤波,在250 Hz的测量速率下,以低于±0.1°C的精度,证明了达到并保持41°C的选定目标温度的能力。像MPC这样的基于优化的控制技术的主要优点是它们能够严格确保约束,例如温度限制,从而在视网膜激光照射期间实现更可靠和安全的温度控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate
Abstract Laser photocoagulation is one of the most frequently used treatment approaches in ophthalmology for a variety of retinal diseases. Depending on indication, treatment intensity varies from application of specific micro injuries down to gentle temperature increases without inducing cell damage. Especially for the latter, proper energy dosing is still a challenging issue, which mostly relies on the physician’s experience. Pulsed laser photoacoustic temperature measurement has already proven its ability for automated irradiation control during laser treatment but suffers from a comparatively high instrumental effort due to combination with a conventional continuous wave treatment laser. In this paper, a simplified setup with a single pulsed laser at 10 kHz repetition rate is presented. The setup combines the instrumentation for treatment as well as temperature measurement and control in a single device. In order to compare the solely pulsed heating with continuous wave (cw) tissue heating, pulse energies of 4 µJ were applied with a repetition rate of 1 kHz to probe the temperature rise, respectively. With the same average laser power of 60 mW an almost identical temporal temperature course was retrieved in both irradiation modes as expected. The ability to reach and maintain a chosen aim temperature of 41 °C is demonstrated by means of model predictive control (MPC) and extended Kalman filtering at a the measurement rate of 250 Hz with an accuracy of less than ±0.1 °C. A major advantage of optimization-based control techniques like MPC is their capability of rigorously ensuring constraints, e.g., temperature limits, and thus, realizing a more reliable and secure temperature control during retinal laser irradiation.
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
23
期刊介绍: Advanced Optical Technologies is a strictly peer-reviewed scientific journal. The major aim of Advanced Optical Technologies is to publish recent progress in the fields of optical design, optical engineering, and optical manufacturing. Advanced Optical Technologies has a main focus on applied research and addresses scientists as well as experts in industrial research and development. Advanced Optical Technologies partners with the European Optical Society (EOS). All its 4.500+ members have free online access to the journal through their EOS member account. Topics: Optical design, Lithography, Opto-mechanical engineering, Illumination and lighting technology, Precision fabrication, Image sensor devices, Optical materials (polymer based, inorganic, crystalline/amorphous), Optical instruments in life science (biology, medicine, laboratories), Optical metrology, Optics in aerospace/defense, Simulation, interdisciplinary, Optics for astronomy, Standards, Consumer optics, Optical coatings.
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