喂食不同水平L-肉碱的黄尾四尾鲎的动物技术性能、脂肪变性程度和遗传毒性潜力

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES

Arquivo Brasileiro De Medicina Veterinaria E Zootecnia Pub Date : 2023-07-01 DOI:10.1590/1678-4162-12934

L. F. Martins, W. V. Silva, N. F. Nascimento, M. P. Melo, B. Crispim, A. Barufatti, C. C. Hilbig

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引用次数: 0

摘要

摘要L-肉碱在将长链脂肪酸输送到线粒体中并在线粒体中被氧化方面发挥着重要作用。它已被用于动物饮食中，以减少脂肪和增加肌肉蛋白质。本研究的目的是评估喂食不同水平的L-肉碱（LC）的Astyanax lacustris的动物技术性能、肝脏脂肪变性程度和遗传毒性潜力。在温度受控（27±0.1）的水循环系统中，黄尾四尾幼体（n=140）分布在20个70L的水箱中，每个水箱中有7条鱼⁰C）。补充不同水平L-肉碱的处理为：0（对照）、250、500、750和1000mg LC/kg食物。每天两次，连续60天。结果表明，不同水平的LC对增重、存活率、内脏指数无影响（P>0.05），肝细胞外观正常。然而，在浓度高于500mg kg-1时，补充LC的使用显示出遗传毒性潜力，与对照相比，细胞变化具有显著差异（P<0.05）。

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Zootechnical performance, degree of steatosis and the genotoxic potential in yellowtail tetra Astyanax lacustris fed with different levels of L-carnitine

ABSTRACT L-carnitine perform a major role in transporting long-chain fatty acids into the mitochondria, where they are oxidized. It has been used in animal diets to decrease fat and increase muscle protein. The aim of this study was to evaluate the zootechnical performance, degree of steatosis in the liver, and genotoxic potential in Astyanax lacustris fed with different levels of L-carnitine (LC). Yellowtail tetra juveniles (n = 140) were distributed in 20 tanks of 70 L, with seven fish in each, in a water recirculation system with controlled temperature (27±0.1⁰C). The treatments with different levels of L-carnitine supplementation were: 0 (control), 250, 500, 750, and 1000 mg of LC per kg of food. The diets were provided twice a day for 60 days. The results showed that the different levels of LC did not affect (P>0.05) weight gain, survival, viscerosomatic index, and the liver hepatocytes showed a normal appearance. However, the use of LC supplementation showed genotoxic potential with a significant difference (P<0.05) for cell alterations when compared to the control at concentrations above 500mg kg-1.

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来源期刊

Arquivo Brasileiro De Medicina Veterinaria E Zootecnia 农林科学-兽医学

CiteScore

0.80

自引率

25.00%

发文量

111

审稿时长

9-18 weeks

期刊介绍： Publica artigos originais de pesquisa sobre temas de medicina veterinária, zootecnia, tecnologia e inspeção de produtos de origem animal e áreas afins relacionadas com a produção animal. Atualmente a revista mantém 628 permutas (419 internacionais e 209 nacionais), sendo um verdadeiro suporte para o recebimento de periódicos pela Biblioteca da Escola. A partir de 1999, a Escola de Veterinária delegou à FEP MVZ Editora o encargo do gerenciamento e edição de todas suas publicações, inclusive do Arquivo, ficando somente com o apoio logístico (instalações, equipamentos, pessoal etc.). O apoio financeiro é exercido pelo CNPq/FINEP e pela própria FEP MVZ.