针刺治疗轻中度阻塞性睡眠呼吸暂停综合征的疗效:一项随机对照临床试验方案☆

IF 0.6 4区 医学 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE
An-qi SHI (石安琪) , Zi-chen WANG (王子辰) , Xiao-huan QI (齐晓环) , Ying DUAN (段莹) , Xu WANG (王旭) , Jian-wei HUO (霍建伟) , Yi-chao CHEN (陈懿超) , Zhi-yuan HUI (惠志远) , Jun WANG (王军) , Chao-qun YAN (闫超群)
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引用次数: 1

摘要

梗阻性睡眠呼吸暂停综合征(OSAS)因其高患病率和严重后果被认为是一个重大的公共卫生问题。一些已发表的研究表明,电针可以缓解OSAS症状。然而,电针治疗OSAS患者的机制尚不清楚。方法:观察电针治疗阻塞性睡眠呼吸暂停综合征的疗效及机制。这是一项两组平行随机对照试验。60例OSAS患者按1:1的比例随机分为电针组和浅针组,分别进行36次电针/浅针治疗(每周3次,持续12周,每次20分钟)。Epworth嗜睡量表(ESS)将被用作主要结果。次要结果包括多导睡眠图(PSG)、睡眠质量、情绪状态和认知功能。此外,患者将在整个针灸治疗前后接受神经成像扫描,以评估神经可塑性的变化,包括灰质密度、白质完整性和功能连接。预期结果:我们认为电针治疗轻中度OSAS患者更有效,针刺治疗后患者的认知和情绪状况将得到改善。此外,我们的目标是澄清哪些脑区可以通过针灸改变OSAS患者。本随机临床试验旨在探讨针刺治疗阻塞性睡眠呼吸暂停症的疗效及主要机制。我们将利用功能磁共振成像技术探索大脑的灰质密度、白质完整性和功能连接。本研究结果对临床osaas治疗指导具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The efficacy of acupuncture for patients with mild to moderate obstructive sleep apnea syndrome: A protocol for a randomized controlled clinical trial

Introduction

Obstructive sleep apnea syndrome (OSAS) is considered a major public health issue due to its high prevalence and severe consequences. Several published studies have revealed that electro-acupuncture may relieve OSAS symptoms. However, the mechanism of electro-acupuncture in the treatment of patients with OSAS remains unclear.

Methods and analysis

We evaluated the efficacy and mechanism of electro-acupuncture in the treatment of patients with OSAS. This was a two-group parallel randomized controlled trial. Sixty patients with OSAS will be randomly divided into an electro-acupuncture or shallow acupuncture group in a proportion of 1:1, and the patients will be administered 36 sessions of electro/shallow acupuncture treatment (three times a week for 12 weeks, 20 min for each session). The Epworth Sleepiness Scale (ESS) will be used as the primary outcome. Secondary outcomes will include polysomnography (PSG), sleep quality, emotional state, and cognitive function. In addition, patients will receive neuroimaging scanning before and after the entire acupuncture treatment to evaluate neuroplasticity changes, including gray matter density, white matter integrity, and functional connections.

Expected outcomes

We believe that the use of electro-acupuncture will be more effective in patients with mild to moderate OSAS and that the cognitive and emotional status of patients will improve after acupuncture treatment. In addition, we aim to clarify which brain areas can be altered by acupuncture in patients with OSAS.

Discussion

This randomized clinical trial aims to explore the curative effect and central mechanism of acupuncture treatment for OSAS. We will explore gray matter density, white matter integrity, and functional connections of the brain using fMRI technology. The results of this study will be significant to the guidelines for clinical OSAS treatment.

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来源期刊
World Journal of Acupuncture-Moxibustion
World Journal of Acupuncture-Moxibustion INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
1.30
自引率
28.60%
发文量
1089
审稿时长
50 days
期刊介绍: The focus of the journal includes, but is not confined to, clinical research, summaries of clinical experiences, experimental research and clinical reports on needling techniques, moxibustion techniques, acupuncture analgesia and acupuncture anesthesia.
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