新型杂环6-(1,3-二苯基- 1h -吡唑-4-基)-4-氧-2-硫氧-1,2,3,4-四氢嘧啶-5-碳腈的细胞毒性和抗菌活性

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2019-01-01 DOI:10.1515/hc-2019-0008

S. K. Ramadan, E. El‐Helw, H. A. Sallam

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引用次数: 25

摘要

摘要制备了一种嘧啶硫酮衍生物，即6-(1,3-二苯基- 1h -吡唑-4-基)-4-氧-2-硫-1,2,3,4-四氢嘧啶-5-碳腈，并与碳亲电试剂反应，试图合成选定的融合杂环。研究了6-(1,3-二苯基- 1h -吡唑-4-基)-4-氧-2-硫氧-1,2,3,4-四氢嘧啶-5-碳腈对氮亲核试剂的反应性。研究了四氢嘧啶衍生物的硫化反应和水解反应。部分合成产物的抗肿瘤和抗菌活性评价显示出良好的结果。

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Cytotoxic and antimicrobial activities of some novel heterocycles employing 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

Abstract A pyrimidinethione derivative namely, 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile, was readily synthesized and reacted with carbon electrophiles in an attempt to synthesize selected fused heterocycles. The reactivity of 6-(1,3-diphenyl-1H-pyrazol-4-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carbonitrile was investigated towards selected nitrogen nucleophiles. Thiation and hydrolysis reactions of the tetrahydropyrimidine derivative were investigated. Antitumor and antimicrobial activity evaluation of some of the synthesized products exhibited promising results.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.