微小RNA和外泌体对肌肉健康和疾病的影响

IF 1.8 3区 生物学 Q4 CELL BIOLOGY
Ngoc Thien Lam, Melanie Gartz, Leah Thomas, Margaret Haberman, Jennifer L Strande
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引用次数: 12

摘要

microRNAs是一种短的(18-22 nt)非编码rna,由于其在转录后水平调控基因表达的能力,参与了重要的细胞过程。外泌体是一种小的(50- 200nm)细胞外囊泡,由多种活细胞自然分泌,被认为通过多种机制介导细胞间的通讯,包括目的细胞的摄取。循环microrna和外泌体衍生的microrna在调节肌肉细胞发育和分化中发挥关键作用。一些microrna在肌肉中高度表达,它们的调节对肌细胞稳态很重要。肌肉相关microRNA表达的变化与肌肉疾病相关,包括肌营养不良症、炎症性肌病和先天性肌病。在这篇综述中,我们旨在重点介绍microRNAs和外泌体的生物学及其在肌肉健康和疾病中的作用。我们还讨论了通过外泌体及其内容物在骨骼肌和心肌之间潜在的串扰。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of microRNAs and exosomes in muscle health and diseases.

microRNAs are short, (18-22 nt) non-coding RNAs involved in important cellular processes due to their ability to regulate gene expression at the post-transcriptional level. Exosomes are small (50-200 nm) extracellular vesicles, naturally secreted from a variety of living cells and are believed to mediate cell-cell communication through multiple mechanisms, including uptake in destination cells. Circulating microRNAs and exosome-derived microRNAs can have key roles in regulating muscle cell development and differentiation. Several microRNAs are highly expressed in muscle and their regulation is important for myocyte homeostasis. Changes in muscle associated microRNA expression are associated with muscular diseases including muscular dystrophies, inflammatory myopathies, and congenital myopathies. In this review, we aim to highlight the biology of microRNAs and exosomes as well as their roles in muscle health and diseases. We also discuss the potential crosstalk between skeletal and cardiac muscle through exosomes and their contents.

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来源期刊
CiteScore
6.20
自引率
0.00%
发文量
21
审稿时长
>12 weeks
期刊介绍: The Journal of Muscle Research and Cell Motility has as its main aim the publication of original research which bears on either the excitation and contraction of muscle, the analysis of any one of the processes involved therein, the processes underlying contractility and motility of animal and plant cells, the toxicology and pharmacology related to contractility, or the formation, dynamics and turnover of contractile structures in muscle and non-muscle cells. Studies describing the impact of pathogenic mutations in genes encoding components of contractile structures in humans or animals are welcome, provided they offer mechanistic insight into the disease process or the underlying gene function. The policy of the Journal is to encourage any form of novel practical study whatever its specialist interest, as long as it falls within this broad field. Theoretical essays are welcome provided that they are concise and suggest practical ways in which they may be tested. Manuscripts reporting new mutations in known disease genes without validation and mechanistic insight will not be considered. It is the policy of the journal that cells lines, hybridomas and DNA clones should be made available by the developers to any qualified investigator. Submission of a manuscript for publication constitutes an agreement of the authors to abide by this principle.
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