Comparative evaluation of nanocrystalline hydroxyapatite bone graft with and without autologous platelet-rich fibrin in the treatment of intrabony defectss

Introduction: Periodontal disease leads to the destruction of the supporting periodontal structures. Treatment of the disease would include regeneration of the lost apparatus, and various materials such as non-crystalline hydroxyapatite have been researched for the same. This study aims to evaluate the efficacy of nanocrystalline hydroxyapatite (nano-HA) as a grafting material with and without platelet-rich fibrin (PRF) in treating intrabony defects (IBDs). Materials and Methods: A total of 30 sites with IBDs were included in the study according to the inclusion and exclusion criteria. Fifteen sites were allotted in the control group (nano-HA alone) and the other 15 were allotted to the test group (nano-HA + PRF). Clinical parameters, including gingival margin (GM), probing depth (PD) and relative attachment levels (RAL), were recorded at baseline, 3 months and 6 months. The radiographic analysis included the percentage of bone fill from baseline to 6 months. Results: The intragroup analysis showed that both groups showed statistically significant results in PD reduction and RALs from baseline to 3 months and baseline to 6 months and percentage of bone fill from baseline to 6 months. No statistical significance was observed for GM. Intergroup analysis showed that the test group (nano-HA + PRF) showed statistically significant results for PD and RAL. GM and radiographic analysis did not show statistical significance. Conclusion: PRF with nano-HA gives additive effects in the regeneration of the IBD.