体外膜氧合成功治疗氧化氮暴露肺损伤2例报告并文献复习

IF 2 4区医学 Q4 TOXICOLOGY

Inhalation Toxicology Pub Date : 2022-05-03 DOI:10.1080/08958378.2022.2070690

Jian Liu, Yong-Quan Dong, Xuejie Li, Weifang Wu

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引用次数: 0

摘要

背景:严重的氮氧化物中毒可导致危及生命的肺损伤。方法:我们报告2例重症氮氧化物性缺氧患者采用静脉-静脉体外膜氧合(ECMO)治疗。暴露后，尽管吸入氧气比例为100%，最大机械通气，但两例患者的病情仍继续恶化;因此，我们开始静脉-静脉ECMO。2例患者从出现到开始ECMO的时间分别为1天和2天。ECMO支持后低氧血症和呼吸衰竭迅速改善。结果:患者出院无并发症。2例患者ECMO持续时间分别为5天和6天。结论:本报告描述了早期ECMO支持如何用于治疗暴露于氮氧化物后可能致命的肺损伤。ECMO运行的持续时间是患者生存的关键决定因素。

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Successful treatment of pulmonary injury due to nitrogen oxide exposure with extracorporeal membrane oxygenation: a report of two cases and literature review

Abstract Background: Severe nitrogen oxide poisoning can lead to life-threatening pulmonary injury. Methods: we report two cases of severe nitrogen-oxide-induced hypoxia treated with veno-venous extracorporeal membrane oxygenation (ECMO). After exposure, the conditions of both patients continued to deteriorate despite maximal mechanical ventilation with a fraction of inspired oxygen of 100%; therefore, we started veno-venous ECMO. The times from presentation to the initiation of ECMO in the two patients were 1 and 2 days. The hypoxemia and respiratory failure improved quickly after ECMO support. Results: The patients were discharged without complications. The durations of ECMO for the two patients were 5 and 6 days. Conclusion: This report describes how early ECMO support was used to treat potentially fatal pulmonary injury after exposure to nitrogen oxide. The duration of the ECMO run is a critical determinant of patient survival.

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来源期刊

Inhalation Toxicology 医学-毒理学

CiteScore

4.10

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Inhalation Toxicology is a peer-reviewed publication providing a key forum for the latest accomplishments and advancements in concepts, approaches, and procedures presently being used to evaluate the health risk associated with airborne chemicals. The journal publishes original research, reviews, symposia, and workshop topics involving the respiratory system’s functions in health and disease, the pathogenesis and mechanism of injury, the extrapolation of animal data to humans, the effects of inhaled substances on extra-pulmonary systems, as well as reliable and innovative models for predicting human disease.