控制工程与合成生物学:基础与应用

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Iacopo Ruolo , Sara Napolitano , Davide Salzano , Mario di Bernardo , Diego di Bernardo
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引用次数: 11

摘要

合成生物学能够构建新的遗传回路,最终目标是控制细胞行为。然而,生物分子相互作用的嘈杂性质使得对这种电路的精确调节是其正确运作所必需的。一个可能的解决方案是控制遗传学,这是一门融合了合成生物学和控制论工具的新学科。生物分子控制器可分为三种不同的类别:(i)嵌入式,其中控制器被实现为与待控制过程共存于同一细胞中的遗传电路;(ii)外部,即控制器作为计算机中的软件实现;(iii)多细胞,其中控制器和被控制的过程位于两个不同的细胞群中。在这里,我们描述了每种方法的优点和缺点,阐述了它们的主要优点、局限性和应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Control engineering meets synthetic biology: Foundations and applications

Control engineering meets synthetic biology: Foundations and applications

Synthetic Biology enables the construction of new genetic circuits with the final goal of controlling cellular behaviour. However, the noisy nature of biomolecular interactions renders a fine regulation of such circuits necessary for their correct operation. A possible solution is cybergenetics, a new discipline merging the tools of Synthetic biology with those of control theory. Biomolecular controllers can be classified into three different categories (i) embedded, in which the controller is implemented as a genetic circuit co-existing in the same cell with the process to be controlled; (ii) external, where the controller is implemented as a software in a computer; (iii) multicellular, in which the controller and the process to be controlled are in two different cell populations. Here, we describe the advantages and drawbacks of each one of the approaches, expounding their main advantages, limitations, and applications.

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来源期刊
Current Opinion in Systems Biology
Current Opinion in Systems Biology Mathematics-Applied Mathematics
CiteScore
7.10
自引率
2.70%
发文量
20
期刊介绍: Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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