脑组织中血管网络、血流和代谢产物分布建模的方法

IF 4.9 Q1 BIOPHYSICS
Biophysical reviews Pub Date : 2023-08-18 eCollection Date: 2023-10-01 DOI:10.1007/s12551-023-01106-0
Veronika Kopylova, Stanislav Boronovskiy, Yaroslav Nartsissov
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引用次数: 0

摘要

心血管系统在营养物质的运输中起着关键作用,确保身体所有细胞持续供应生命所需的代谢物。大脑的血液供应是由位于其表面的大动脉进行的,这些大动脉分支成更小的小动脉,这些小动脉穿过大脑皮层并喂养毛细血管床,从而形成一个广泛的分支网络。血管的形成是通过血管发生和血管生成来完成的,它们在胚胎和成人生活中都起着重要的作用。这篇综述介绍了对血管网络形成和形成的动脉树的构建的各个方面进行建模的方法。此外,还简要描述了一些模型,这些模型允许人们研究循环系统各部分的血流和脑组织中代谢物的时空分布。由于心血管系统的复杂性和所有身体细胞进行灌注的机制,对这些问题的实验研究并不总是可能的。在这方面,数学模型是研究血流动力学的一个很好的工具,可以在临床实践中用于诊断血管疾病和评估治疗的需要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Approaches to vascular network, blood flow, and metabolite distribution modeling in brain tissue.

The cardiovascular system plays a key role in the transport of nutrients, ensuring a continuous supply of all cells of the body with the metabolites necessary for life. The blood supply to the brain is carried out by the large arteries located on its surface, which branch into smaller arterioles that penetrate the cerebral cortex and feed the capillary bed, thereby forming an extensive branching network. The formation of blood vessels is carried out via vasculogenesis and angiogenesis, which play an important role in both embryo and adult life. The review presents approaches to modeling various aspects of both the formation of vascular networks and the construction of the formed arterial tree. In addition, a brief description of models that allows one to study the blood flow in various parts of the circulatory system and the spatiotemporal metabolite distribution in brain tissues is given. Experimental study of these issues is not always possible due to both the complexity of the cardiovascular system and the mechanisms through which the perfusion of all body cells is carried out. In this regard, mathematical models are a good tool for studying hemodynamics and can be used in clinical practice to diagnose vascular diseases and assess the need for treatment.

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来源期刊
Biophysical reviews
Biophysical reviews Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
8.90
自引率
0.00%
发文量
93
期刊介绍: Biophysical Reviews aims to publish critical and timely reviews from key figures in the field of biophysics. The bulk of the reviews that are currently published are from invited authors, but the journal is also open for non-solicited reviews. Interested authors are encouraged to discuss the possibility of contributing a review with the Editor-in-Chief prior to submission. Through publishing reviews on biophysics, the editors of the journal hope to illustrate the great power and potential of physical techniques in the biological sciences, they aim to stimulate the discussion and promote further research and would like to educate and enthuse basic researcher scientists and students of biophysics. Biophysical Reviews covers the entire field of biophysics, generally defined as the science of describing and defining biological phenomenon using the concepts and the techniques of physics. This includes but is not limited by such areas as: - Bioinformatics - Biophysical methods and instrumentation - Medical biophysics - Biosystems - Cell biophysics and organization - Macromolecules: dynamics, structures and interactions - Single molecule biophysics - Membrane biophysics, channels and transportation
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