非小细胞肺癌患者外周血白细胞端粒DNA长度与肿瘤类型及预后的关系

中国综合临床 Pub Date : 2019-11-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2019.06.001

R. Wu, Lyu-Han Wang, Lu Gao, Liang Li, L. Zhong, Yi Zhang, C. Gao, Xiaoyong Han

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引用次数: 0

摘要

目的探讨非小细胞肺癌(NSCLC)外周血白细胞端粒DNA长度与肿瘤类型及预后的关系。方法选取2016年6月至2017年4月河北省保定市第一中心医院胸外科住院患者为研究对象。经病理检查确认为肺癌及TNM分期的患者，排除一般记录不详及失诊的患者。最终纳入55例患者，其中腺癌组35例，其他非小细胞肺癌组20例。采用实时荧光定量PCR检测非小细胞肺癌患者外周血白细胞端粒DNA长度，并随访患者生存情况，分析外周血白细胞端粒DNA长度与肿瘤病理分型及预后的关系。结果腺癌组端粒DNA长度(T/s)(1.98±0.69)大于其他非小细胞肺癌组(1.43±0.67)，P=0.007;不同TNM分期患者外周血白细胞端粒DNA长度差异无统计学意义。根据外周血端粒DNA长度，短端粒组患者的平均生存时间为17.149个月(95%CI=14.696~19.602)，显著低于长端粒组患者的平均生存时间30.857个月(95%CI= 28.515~33.199)，差异有统计学意义(P=0.001);Cox比例风险回归分析显示:端粒DNA长度(P=0.041)、肿瘤分期(P=0.007)是影响患者预后的独立危险因素。结论肺腺癌患者外周血白细胞端粒DNA长度明显长于其他非小细胞肺癌，TNM分期和外周血白细胞端粒DNA长度是影响非小细胞肺癌预后的独立危险因素。关键词:非小细胞肺癌;端粒DNA长度;肺癌;预后

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Relationship between telomere DNA length of peripheral leukocytes and tumor type and prognosis in patients with non-small cell lung cancer

Objective To investigate the relationship between telomere DNA length of peripheral leukocytes and tumor type and prognosis in non-small cell lung cancer (NSCLC). Methods From June 2016 to April 2017, the thoracic surgery department of Baoding First Central Hospital, Hebei Province was included in the study.The patients with lung cancer and TNM stage were confirmed by pathological examination, excluding the patients with unknown general records and lost visits.Finally, 55 patients were included, including 35 patients in adenocarcinoma group and 20 patients in other non-small cell lung cancer group.The telomere DNA length of peripheral blood leukocytes in patients with non-small cell lung cancer was detected by real-time fluorescence quantitative PCR, and the survival of patients was followed up to analyze the relationship between telomere DNA length of peripheral blood leukocytes and tumor pathological type and prognosis. Results The telomere DNA length (T/s) (1.98±0.69) of adenocarcinoma group was larger than that of other non-small cell lung cancer group (1.43±0.67), P=0.007; there was no significant difference in the telomere DNA length of peripheral blood leukocytes in patients with different TNM stages.According to the length of telomere DNA in peripheral blood, the average survival time of short telomere group was 17.149 months(95%CI=14.696~19.602), which was significantly lower than that of long telomere group (30.857 months, 95%CI=28.515~33.199), the difference was statistically significant (P=0.001); Cox proportional risk regression analysis showed that: telomere DNA length (P=0.041), tumor stage (P=0.007) were independent risk factors for prognosis of patients. Conclusion Telomere DNA length of peripheral blood leukocytes in patients with lung adenocarcinoma is longer than that of other non-small cell lung cancer, and TNM stage and telomere DNA length of peripheral blood leukocytes are independent risk factors for prognosis of non-small cell lung cancer. Key words: Non-small cell lung cancer; Telomere DNA length; Lung cancer; Prognosis

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.