S.M. Valle , A. Alexandrov , G. Ambrosi , S. Argirò , G. Battistoni , N. Belcari , S. Biondi , M.G. Bisogni , G. Bruni , S. Brambilla , N. Camarlinghi , P. Cerello , E. Ciarrocchi , A. Clozza , G. De Lellis , A. Di Crescenzo , M. Durante , M. Emde , R. Faccini , V. Ferrero , A. Zoccoli
{"title":"FOOT:一项测量中等能量下核碎片的新实验","authors":"S.M. Valle , A. Alexandrov , G. Ambrosi , S. Argirò , G. Battistoni , N. Belcari , S. Biondi , M.G. Bisogni , G. Bruni , S. Brambilla , N. Camarlinghi , P. Cerello , E. Ciarrocchi , A. Clozza , G. De Lellis , A. Di Crescenzo , M. Durante , M. Emde , R. Faccini , V. Ferrero , A. Zoccoli","doi":"10.1016/j.pisc.2019.100415","DOIUrl":null,"url":null,"abstract":"<div><p>Charged particle therapy exploits proton or <sup>12</sup>C beams to treat deep-seated solid tumors. Due to the advantageous characteristics of charged particles energy deposition in matter, the maximum of the dose is released to the tumor at the end of the beam range, in the Bragg peak region. However, the beam nuclear interactions with the patient tissues induces fragmentation both of projectile and target nuclei and needs to be carefully taken into account. 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引用次数: 6
摘要
带电粒子疗法利用质子或12C束来治疗深部实体肿瘤。由于带电粒子能量在物质中沉积的有利特性,最大剂量在光束范围的末端,即布拉格峰区域释放到肿瘤。然而,束核与患者组织的相互作用会引起抛射核和靶核的碎裂,需要仔细考虑。在质子治疗中,靶碎片沿整个光束范围产生低能量、短程碎片,在进入通道中沉积不可忽略的剂量。在12C治疗中,主要关注的是由于光束碎片在肿瘤以外的健康组织中释放其剂量而产生的远程碎片。为了改进下一代治疗计划系统中对核碎片的描述,提高治疗计划的质量,设计了INFN的靶碎片化实验(FOOT experiment Of Target)来研究这些过程。治疗能量的质子束诱导靶(16O和12C核)碎裂将通过逆运动学方法进行研究,其中16O和12C治疗束撞击石墨和碳氢化合物靶,以提供氢的核碎裂截面。还将探索16O和12C光束的弹丸破片。FOOT探测器包括一个用于碎片动量测量的磁谱仪,一个用于ΔE和飞行时间测量的塑料闪烁体和一个用于测量碎片动能的晶体量热计。这些测量结果将被结合起来,以便做出准确的碎片电荷和同位素鉴定。
FOOT: a new experiment to measure nuclear fragmentation at intermediate energies
Charged particle therapy exploits proton or 12C beams to treat deep-seated solid tumors. Due to the advantageous characteristics of charged particles energy deposition in matter, the maximum of the dose is released to the tumor at the end of the beam range, in the Bragg peak region. However, the beam nuclear interactions with the patient tissues induces fragmentation both of projectile and target nuclei and needs to be carefully taken into account. In proton treatments, target fragmentation produces low energy, short range fragments along all the beam range, which deposit a non negligible dose in the entry channel. In 12C treatments the main concern is represented by long range fragments due to beam fragmentation that release their dose in the healthy tissues beyond the tumor. The FOOT experiment (FragmentatiOn Of Target) of INFN is designed to study these processes, in order to improve the nuclear fragmentation description in next generation Treatment Planning Systems and the treatment plans quality. Target (16O and 12C nuclei) fragmentation induced by –proton beams at therapeutic energies will be studied via an inverse kinematic approach, where 16O and 12C therapeutic beams impinge on graphite and hydrocarbon targets to provide the nuclear fragmentation cross section on hydrogen. Projectile fragmentation of 16O and 12C beams will be explored as well. The FOOT detector includes a magnetic spectrometer for the fragments momentum measurement, a plastic scintillator for ΔE and time of flight measurements and a crystal calorimeter to measure the fragments kinetic energy. These measurements will be combined in order to make an accurate fragment charge and isotopic identification.