铁下垂相关的长非编码RNA在泌尿系肿瘤中的作用

Wen-chao Xie, Jie Gu, Zhenqian Qin, Yimin Xie
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引用次数: 0

摘要

脱铁症是一种程序性细胞死亡,最近在癌症治疗中引起了人们的兴趣。越来越多的证据表明,长非编码RNA(lncRNA)参与脱铁性贫血,并与癌症的发病率和进展有关。然而,lncRNA与泌尿系癌症脱铁症之间的关系尚未完全阐明。在这篇综述中,我们总结了泌尿系统癌症中与脱铁相关的lncRNA(frlncRNA)。研究表明frlncRNA与癌症代谢、肿瘤微环境和免疫细胞浸润有关。此外,frlncRNA可以在mRNA和蛋白质水平上调节脱铁相关基因。因此,深入了解frlncRNA在泌尿系统癌症发生和发展中的作用,将为开发抗癌疗法提供新的信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Roles of Ferroptosis-related Long Non-coding RNAs in Urologic Cancers
Ferroptosis is a type of programmed cell death that has been recent topic of interest in cancer therapy. Growing evidence indicates that long noncoding RNAs (lncRNAs) are involved in ferroptosis and associated with the incidence and progression of cancer. However, the relationship between lncRNA and ferroptosis in urologic cancers has not been fully elucidated. In this review, we summarize ferroptosis-related lncRNAs (frlncRNAs) in urologic cancers. Studies indicate that frlncRNAs are associated with cancer metabolism, tumor microenvironment, and immune cell infiltration. In addition, frlncRNAs could regulate ferroptosis related genes both at the mRNA and protein level. Therefore, a deep understanding of the roles of frlncRNAs in urologic cancers occurrence and progression will provide novel information for the development of anticancer therapies.
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