Quantum Dots and Gd3+ Chelates: Advances and Challenges Towards Bimodal Nanoprobes for Magnetic Resonance and Optical Imaging

The development of multimodal nanoprobes has been growing?in recent years. Among these novel nanostructures are bimodal systems based on quantum dots (QDs) and low molecular weight Gd³⁺ chelates, prepared for magnetic resonance imaging (MRI) and optical analyses. MRI is a technique used worldwide that provides anatomic resolution and allows distinguishing of physiological differences at tissue and organ level. On the other hand, optical techniques are very sensitive and allow events to be followed at the cellular or molecular level. Thus, the association of these two techniques has the potential to achieve a more complete comprehension of biological processes. In this review, we present state-of-the-art research concerning the development of potential multimodal optical/paramagnetic nanoprobes based on Gd³⁺ chelates and QDs, highlighting their preparation strategies and overall properties.