{"title":"神经退行性疾病和痴呆","authors":"Blossom Samuel Affia","doi":"10.37191/mapsci-2582-4937-2(2)-021","DOIUrl":null,"url":null,"abstract":"Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), front temporal dementia (FTD) and Huntington’s disease (HD show some clinical, morbid and molecular overlapping [1]. PD is one of the most common neurodegenerative disorders. Dopaminergic neurons in the substantia nigra pars compacta degenerate and die, which forms the basis of the disease [2]. As the disease intensifies with the passage of time, many people develop dementia, and other mental abilities in later stages [3]. Loss of dopaminergic neurons causes prominent and projecting symptoms like involuntary tremor, rigidity, postural instability, gait, speech problems and akinesia [4]. One accepted and efficient convention for generating dopaminergic neurons in vitro is the combination of several pharmacological compounds and molecules. A broad general evaluation of neurodegeneration is discussed in this article.","PeriodicalId":87293,"journal":{"name":"Journal of biomedical and allied research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neurodegeneration- Disease And Dementia\",\"authors\":\"Blossom Samuel Affia\",\"doi\":\"10.37191/mapsci-2582-4937-2(2)-021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), front temporal dementia (FTD) and Huntington’s disease (HD show some clinical, morbid and molecular overlapping [1]. PD is one of the most common neurodegenerative disorders. Dopaminergic neurons in the substantia nigra pars compacta degenerate and die, which forms the basis of the disease [2]. As the disease intensifies with the passage of time, many people develop dementia, and other mental abilities in later stages [3]. Loss of dopaminergic neurons causes prominent and projecting symptoms like involuntary tremor, rigidity, postural instability, gait, speech problems and akinesia [4]. One accepted and efficient convention for generating dopaminergic neurons in vitro is the combination of several pharmacological compounds and molecules. A broad general evaluation of neurodegeneration is discussed in this article.\",\"PeriodicalId\":87293,\"journal\":{\"name\":\"Journal of biomedical and allied research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-08-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of biomedical and allied research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37191/mapsci-2582-4937-2(2)-021\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biomedical and allied research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37191/mapsci-2582-4937-2(2)-021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Parkinson’s disease (PD), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), front temporal dementia (FTD) and Huntington’s disease (HD show some clinical, morbid and molecular overlapping [1]. PD is one of the most common neurodegenerative disorders. Dopaminergic neurons in the substantia nigra pars compacta degenerate and die, which forms the basis of the disease [2]. As the disease intensifies with the passage of time, many people develop dementia, and other mental abilities in later stages [3]. Loss of dopaminergic neurons causes prominent and projecting symptoms like involuntary tremor, rigidity, postural instability, gait, speech problems and akinesia [4]. One accepted and efficient convention for generating dopaminergic neurons in vitro is the combination of several pharmacological compounds and molecules. A broad general evaluation of neurodegeneration is discussed in this article.