含4-氨基吡啶配体锌(II)配合物的合成、结构测定及抗菌性能

IF 1 Q4 CHEMISTRY, MULTIDISCIPLINARY

Indonesian Journal of Chemistry Pub Date : 2023-08-15 DOI:10.22146/ijc.82801

Wayan Dasna, Dewi Mariyam, H. W. Wijaya, Ubed Sonai, Fahruddin Arrozi, Sugiarto Sugiarto

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引用次数: 0

摘要

合成了3种含4-氨基吡啶(4-NH2py) [Zn(4-NH2py)2(NCS)2](1)、[Zn(4-NH2py)2Cl2](2)和[Zn(4-NH2py)2(NCS)Cl](3)的锌(II)配合物，并用FTIR和单晶x射线衍射对其进行了表征。所有配合物都采用略微扭曲的四面体几何形状，具有不同的晶体填充。配合物1在正交Pmmn空间群结晶，配合物2在单斜C2/c空间群结晶，配合物3在正交Pbca空间群结晶。4-NH2py与其他配体(NCS -和Cl -)之间存在NC-S··H、-Cl··H等非共价相互作用和μ - μ堆叠相互作用。体外对两种细菌(大肠杆菌和金黄色葡萄球菌)进行抑菌筛选。结果表明，1的抑菌活性高于2和3。这种差异是由于阴离子配体引起的相互作用的差异。

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Synthesis, Structural Determination and Antibacterial Properties of Zinc(II) Complexes Containing 4-Aminopyridine Ligands

Three zinc(II) complexes containing 4-aminopyridine (4-NH2py) [Zn(4-NH2py)2(NCS)2] (1), [Zn(4-NH2py)2Cl2] (2), and [Zn(4-NH2py)2(NCS)Cl] (3) were synthesized and characterized by FTIR and single crystal X-ray diffraction. All complexes adopt a slightly distorted tetrahedral geometry with different crystal packing. Complex 1 crystallizes in the orthorhombic Pmmn space group, complex 2 in the monoclinic C2/c space group, and complex 3 in the orthorhombic Pbca space group. Non-covalent interactions such as NC-S···H, -Cl···H, and µ-µ stacking interaction between 4-NH2py and other ligands (NCS− and Cl−) are observed in the crystals packing. In vitro, antibacterial screening of all complexes was evaluated against two bacteria (Escherichia coli and Staphylococcus aureus). The results show that 1 has the highest antibacterial activity than 2 and 3. This difference is due to differences in the interactions elicited by the anion ligands.

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来源期刊

Indonesian Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

11.10%

发文量

106

审稿时长

15 weeks

期刊介绍： Indonesian Journal of Chemistry is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry, including educational chemistry, applied chemistry, and chemical engineering.