2-羟基苯甲醛（2-芳基喹唑啉-4-基）腙的合成及其细胞毒性

Q4 Materials Science

Chimica Techno Acta Pub Date : 2023-05-04 DOI:10.15826/chimtech.2023.10.2.11

E. Nosova, I. Butorin, M. D. Likhacheva, S. Kotovskaya

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引用次数: 0

摘要

以4,5-二氟苯甲酸或蒽酰胺为基料，制备了4位水杨酸肼片段的2-苯基-6,7-二氟和2-(4-氟苯基)喹唑啉衍生物。与酪蛋白激酶2进行分子对接;发现了对CK2具有高硅活性的化合物。研究了合成的化合物对肿瘤细胞株MDA-MB-231和正常细胞株WI26 - VA4的细胞毒活性。

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Synthesis and cytotoxic activity of (2-arylquinazolin-4-yl)hydrazones of 2-hydroxybenzaldehydes

2-Phenyl-6,7-difluoro and 2-(4-fluorophenyl)quinazoline derivatives bearing salicylidenhydrazino fragments at position 4 were prepared based on 4,5-difluoroantranilic acid or anthranilamide. Molecular docking to casein kinase 2 was performed; compounds with high in silico activity to CK2 were revealed. Cytotoxic activity of the synthesized compounds was studied on cancer cell line MDA-MB-231 and normal cell line WI26 VA4.

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来源期刊

Chimica Techno Acta Chemical Engineering-Chemical Engineering (all)

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

4 weeks