木香提取物抗阿霉素致Wistar大鼠肾保护作用

IF 0.9 4区 医学 Q4 PHARMACOLOGY & PHARMACY
M. Rajasekaran
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引用次数: 11

摘要

本研究旨在探讨中药木香对阿霉素致肾毒性的保护作用。将大鼠分为6组,分别给予阿霉素和红花乙醇提取物治疗。阿霉素腹腔注射,每周单剂量(4mg /kg),持续三周。将提取液(200或400 mg/kg)口服给药4周。观察阿霉素给药大鼠血清肾标志物、白蛋白、尿素、尿酸、肌酐、谷胱甘肽过氧化物酶、谷胱甘肽s -转移酶、过氧化氢酶、超氧化物歧化酶、还原性谷胱甘肽和脂质过氧化物的变化。组织学特征也受到严重影响。然而,提取物处理大鼠的生化和组织学变化不显著,表明该草药具有肾保护作用。其效果与抗氧化维生素E相当。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nephroprotective effect of Costus pictus extract against doxorubicin-induced toxicity on Wistar rat
The present study was conducted to evaluate the nephroprotective effect of a medicinal herb Costus pictus against doxorubicin-induced toxicity. Rats were divided into six groups and treated with doxorubicin and ethanol extract of the C. pictus. Doxorubicin was administered intraperitoneally with a single dose (4 mg/kg) per week for three weeks. The extract (200 or 400 mg/kg) was administered orally for 4 weeks to two doxorubicin groups. Significant changes of the serum kidney markers, albumin, urea, uric acid and creatinine, and glutathione peroxidase, glutathione–S-transferase, catalase, superoxide dismutase, reduced glutathione and lipid peroxides in the kidney of doxorubicin-treated rat were observed. Histological features were also severely affected. However, biochemical and histological changes in the extract-treated rat were non-significant, showing that the herb is nephroprotective. The effects were comparable to the anti-oxidant vitamin E.
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来源期刊
Bangladesh Journal of Pharmacology
Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-
CiteScore
1.50
自引率
18.80%
发文量
4
审稿时长
>12 weeks
期刊介绍: Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.
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