阿拉伯胶对动脉粥样硬化大鼠胆固醇合成和血脂的影响

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-04-07 DOI:10.37290/ctnr2641-452x.21:163-168

Abuelgassim Omer Abuelgassim, Abeer Al-Otaibi, Seema Zargar

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引用次数: 0

摘要

在目前的研究中，我们评估了阿拉伯树胶对致动脉粥样硬化大鼠胆固醇稳态的影响。为此，成年雄性Wistar大鼠连续6周口服浓度增加的阿拉伯树胶，并评估胆固醇稳态标志物（总胆固醇、低密度脂蛋白和3-羟基-3-甲基戊二酰辅酶A还原酶活性）的血清浓度。用阿拉伯树胶治疗致动脉粥样硬化大鼠可提高胆固醇稳态标志物的血清水平。此外，阿拉伯树胶对正常对照大鼠的肝组织没有任何有害影响，而动脉粥样硬化治疗大鼠的肝脏组织在愈合、炎症和坏死方面有所改善。总之，阿拉伯树胶可能有助于改善高胆固醇血症患者的胆固醇稳态。

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The Effect of Gum Arabic on Cholesterol Synthesis and Serum Lipids in Atherogenic Rats

In the current study, we have evaluated the effect of gum Arabic on cholesterol homeostasis in atherogenic rats. To this end, adult male Wistar rats were treated orally with increasing concentrations of gum Arabic for 6 consecutive weeks, and serum concentrations of markers of cholesterol homeostasis (total cholesterol, low-density lipoprotein, and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase activity) were evaluated. Treatment of atherogenic rats with gum Arabic improved serum levels of markers of cholesterol homeostasis. Also, gum Arabic did not reveal any harmful effect on the liver tissue of normal control rats, whereas the liver tissue of atherogenic-treated rats showed improvements in healing, inflammation, and necrosis. In conclusion, gum Arabic may serve to improve cholesterol homeostasis in patients with hypercholesterolemia.

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.