三种预后生物标志物与膀胱尿路上皮癌免疫检查点阻断反应相关

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

International Journal of Genomics Pub Date : 2022-05-26 DOI:10.1155/2022/3342666

Ya Guo, Yin Bin Zhang, Yi Li, Wang Hui Su, Sha He, S. Pan, Kun Xu, W. Kou

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引用次数: 1

摘要

目的开发一种能够准确预测膀胱尿路上皮癌(BLCA)预后和评价免疫检查点阻断(ICB)应答的标志物。方法在综合分析公共数据库的基础上，确定与预后相关的枢纽基因，并研究其对BLCA患者ICB反应的预测价值。结果69例常见deg中，AURKA、BIRC5、CKS1B 3个基因与预后不良相关，且与组织学亚型、TP53突变状态、C2 (ifn - γ显性)亚型相关。三种基因及其相关风险模型可以有效预测免疫治疗的反应。通过对药库数据库的分析，鉴定出相关药物。结论3个基因可预测BLCA患者的预后和评价ICB的疗效。

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Three Prognostic Biomarkers Correlate with Immune Checkpoint Blockade Response in Bladder Urothelial Carcinoma

Aim We aim to develop a signature that could accurately predict prognosis and evaluate the response to immune checkpoint blockade (ICB) in bladder urothelial carcinoma (BLCA). Methods Based on comprehensive analysis of public database, we identified prognosis-related hub genes and investigated their predictive values for the ICB response in BLCA. Results Among 69 common DEGs, three genes (AURKA, BIRC5, and CKS1B) were associated with poor prognosis, and which were related to histological subtypes, TP53 mutation status, and the C2 (IFN-gamma dominant) subtype. Three genes and their related risk model can effectively predict the response of immunotherapy. Their related drugs were identified through analysis of drug bank database. Conclusions Three genes could predict prognosis and evaluate the response to ICB in BLCA.

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来源期刊

International Journal of Genomics BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： International Journal of Genomics is a peer-reviewed, Open Access journal that publishes research articles as well as review articles in all areas of genome-scale analysis. Topics covered by the journal include, but are not limited to: bioinformatics, clinical genomics, disease genomics, epigenomics, evolutionary genomics, functional genomics, genome engineering, and synthetic genomics.